DESCRIPTION:

QTL associated with systematic lupus erythematosus susceptibility 10. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (19802051)

LABEL:

QTL-Sle10-Mouse-Chr 1

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2020-05-06

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:2149096

AUTHORS:

Haywood ME, Hogarth MB, Slingsby JH, Rose SJ, Allen PJ, Thompson EM, Maibaum MA, Chandler P, Davies KA, Simpson E, Walport MJ, Morley BJ

TITLE:

Identification of intervals on chromosomes 1, 3, and 13 linked to the development of lupus in BXSB mice.

JOURNAL:

Arthritis and rheumatism Feb 2000, Vol 43, pp. 349-55

ABSTRACT:

To identify intervals containing systemic lupus erythematosus (SLE) susceptibility alleles in the BXSB strain of mice.We analyzed 286 (B10 x [B10 x BXSB]F1) backcross mice for a range of phenotypic traits associated with the development of SLE in BXSB mice. The mice were genotyped using 93 microsatellite markers, and the linkage of these markers to disease was studied by extreme-phenotype and quantitative trait locus analysis.The disease phenotype in these backcross mice was less severe than that in BXSB mice. However, antinuclear antibody production was increased compared with the parental strain. We identified 4 areas of genetic linkage to disease on chromosome 1 (Bxs1-4), 1 on chromosome 3 (Bxs5), and another interval on chromosome 13 which were associated with various aspects of the phenotype. Bxs4 and Bxs5 are located in regions not previously linked to disease in other models of SLE.SLE in the BXSB mouse model has a complex genetic basis and involves at least 5 distinct intervals located on chromosomes 1 and 3. There is evidence that different intervals affect particular aspects of the SLE phenotype. PUBMED: 10693874
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