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QTL associated with inflammatory bowel disease QTL 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (57745571)
Authors:
Bamias G, Mishina M, Nyce M, Ross WG, Kollias G, Rivera-Nieves J, Pizarro TT, Cominelli F
Alcohol preference QTL 1 spans 26931283-76931283 (NCBI Build 37) on Chr9. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org). Phenotypically extreme HAP1/LAP1 animals (n=96) and HAP2/LAP2 animals (n=48) were screened for microsatellite markers in chromosomal regions previously reported to influence alcohol preference phenotypes. Linkage to alcohol preference, Alpq1, mapped to chromosome 9 near D9Mit4 (29 cM) in the HAP1/LAP1 set and near D9Mit90 (9 cM) in the HAP2/LAP2 set. The Alpq1 QTL interval is broad and may contain more than 1 underlying gene. Drd2 at 28 cM is a potential candidate for Alpq1.
Authors:
Bice PJ, Foroud T, Carr LG, Zhang L, Liu L, Grahame NJ, Lumeng L, Li TK, Belknap JK
QTL associated with APP associated premature death 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (40462577)
Differential gene expression in nucleus accumbens somatostatin interneurons_cocaine_mice_pvalue
Description:
To characterize transcriptional alterations that cocaine induces in these cells, we perform cell type-specific RNA-sequencing on FACS-isolated nuclei of somatostatin interneurons and identified 1100 DETs enriched for processes related to neural plasticity. To profile the entire (non poly-A selected) transcriptome of NAc somatostatin interneurons, we generated a transgenic reporter line (SST-TLG498 mice) to label the nuclei of these cells with a modified form of EGFP that is retained in the nuclear membrane (EGFP-F)22, enabling their isolation from NAc dissections using FACS. We succeeded in FACS-isolating nuclei suitable for RNA-sequencing from individual SST-TLG498 mice. We proceeded with differential expression analysis of the RNA-sequencing data to identify differentially expressed transcripts (DETs) in NAc somatostatin interneurons in response to repeated cocaine exposure: 778 transcripts were upregulated by cocaine and 322 were downregulated.
Authors:
Efrain A Ribeiro, Marine Salery, Joseph R Scarpa, Erin S Calipari, Peter J Hamilton, Stacy M Ku, Hope Kronman, Immanuel Purushothaman, Barbara Juarez, Mitra Heshmati, Marie Doyle, Casey Lardner, Dominicka Burek, Ana Strat, Stephen Pirpinias, Ezekiell Mouzon, Ming-Hu Han, Rachael L Neve, Rosemary C Bagot, Andrew Kasarskis, Ja Wook Koo, Eric J Nestler
QTL associated with bone response to mechanical loading 5. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (37202486)
QTL for high-dose ethanol actions on Chr9 at D9Mit42 (21.79 Mbp , Build 37)
Description:
high-dose ethanol actions spans 0.00 - 46.79 Mbp (NCBI Build 37) on Chr9. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
Authors:
Erwin VG, Markel PD, Johnson TE, Gehle VM, Jones BC
QTL associated with activity-distance traveled 4. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (49331368)
QTL associated with protection against vaginal candidiasis 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (36839695)
QTL associated with haloperidol-induced catelepsy 5. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (31167847)
QTL associated with cystic fibrosis modifier QTL 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (32308040)
QTL associated with type 2 diabetes modifying QTL 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (46041438)
QTL associated with "body temperature response to dietary restriction, QTL 1". This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (51931283)
Authors:
Rikke BA, Yerg JE 3rd, Battaglia ME, Nagy TR, Allison DB, Johnson TE
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