DESCRIPTION:

QTL associated with type 2 diabetes modifying QTL 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (46041438)

LABEL:

QTL-Tdmq1-Mouse-Chr 9

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2024-04-25

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:3579350

AUTHORS:

Yaguchi H, Togawa K, Moritani M, Itakura M

TITLE:

Identification of candidate genes in the type 2 diabetes modifier locus using expression QTL.

JOURNAL:

Genomics May 2005, Vol 85, pp. 591-9

ABSTRACT:

To identify new genetic determinants relevant to type 2 diabetes (T2D), diabetic F2 progeny were generated by intercrossing F1 mice obtained from a cross of BKS.Cg-Lepr(db)+/+m and DBA/2, and T2D-related phenotypes were measured. In the F2 population, increased susceptibility to diabetes and obesity was observed. We also detected the major quantitative trait loci (QTL) modifying the severity of diabetes on chromosome 9, where peaks of logarithm of odds (LOD) overlapped for three traits. To identify candidate genes in the QTL intervals, we combined "expression QTL" (eQTL), taking mRNA levels as quantitative traits, and "interstrain sequence variations, including cSNPs." As a result, four genes were identified from cosegregation of clinical QTL with eQTL and 13 genes were found from interstrain cSNPs as candidates in the T2D modifier QTL. Our combined approach shows the acceleration of the discovery of candidate genes in the QTL of interest, spanning several megabases. PUBMED: 15820311
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