Differential gene expression in the nucleus accumbens of WT vs SERT Met172 mice after acute cocaine treatment_logFC
Description:
To elucidate 5-HT transporter (SERT)-specific contributions to cocaine action, we evaluated cocaine effects in the SERT Met172 knock-in mouse, which expresses a SERT coding substitution that eliminates high-affinity cocaine recognition. We measured the effects of SERT Met172 on cocaine antagonism of 5-HT re-uptake using ex vivo synaptosome preparations and in vivo microdialysis. We assessed SERT dependence of cocaine actions behaviourally through acute and chronic locomotor activation, sensitization, conditioned place preference (CPP) and oral cocaine consumption.
Authors:
Linda D Simmler, Allison M J Anacker, Michael H Levin, Nina M Vaswani, Paul J Gresch, Alex G Nackenoff, Noelle C Anastasio, Sonja J Stutz, Kathryn A Cunningham, Jing Wang, Bing Zhang, L Keith Henry, Adele Stewart, Jeremy Veenstra-VanderWeele, Randy D Blakely
Differential gene expression in the nucleus accumbens of WT vs SERT Met172 mice after acute cocaine treatment_FDR
Description:
To elucidate 5-HT transporter (SERT)-specific contributions to cocaine action, we evaluated cocaine effects in the SERT Met172 knock-in mouse, which expresses a SERT coding substitution that eliminates high-affinity cocaine recognition. We measured the effects of SERT Met172 on cocaine antagonism of 5-HT re-uptake using ex vivo synaptosome preparations and in vivo microdialysis. We assessed SERT dependence of cocaine actions behaviourally through acute and chronic locomotor activation, sensitization, conditioned place preference (CPP) and oral cocaine consumption.
Authors:
Linda D Simmler, Allison M J Anacker, Michael H Levin, Nina M Vaswani, Paul J Gresch, Alex G Nackenoff, Noelle C Anastasio, Sonja J Stutz, Kathryn A Cunningham, Jing Wang, Bing Zhang, L Keith Henry, Adele Stewart, Jeremy Veenstra-VanderWeele, Randy D Blakely
Differential gene expression in the prelimbic cortex of WT vs SERT Met172 mice after acute cocaine treatment_FDR
Description:
To elucidate 5-HT transporter (SERT)-specific contributions to cocaine action, we evaluated cocaine effects in the SERT Met172 knock-in mouse, which expresses a SERT coding substitution that eliminates high-affinity cocaine recognition. We measured the effects of SERT Met172 on cocaine antagonism of 5-HT re-uptake using ex vivo synaptosome preparations and in vivo microdialysis. We assessed SERT dependence of cocaine actions behaviourally through acute and chronic locomotor activation, sensitization, conditioned place preference (CPP) and oral cocaine consumption.
Authors:
Linda D Simmler, Allison M J Anacker, Michael H Levin, Nina M Vaswani, Paul J Gresch, Alex G Nackenoff, Noelle C Anastasio, Sonja J Stutz, Kathryn A Cunningham, Jing Wang, Bing Zhang, L Keith Henry, Adele Stewart, Jeremy Veenstra-VanderWeele, Randy D Blakely
Differential gene expression in the prelimbic cortex of WT vs SERT Met172 mice after acute cocaine treatment_logFC
Description:
To elucidate 5-HT transporter (SERT)-specific contributions to cocaine action, we evaluated cocaine effects in the SERT Met172 knock-in mouse, which expresses a SERT coding substitution that eliminates high-affinity cocaine recognition. We measured the effects of SERT Met172 on cocaine antagonism of 5-HT re-uptake using ex vivo synaptosome preparations and in vivo microdialysis. We assessed SERT dependence of cocaine actions behaviourally through acute and chronic locomotor activation, sensitization, conditioned place preference (CPP) and oral cocaine consumption.
Authors:
Linda D Simmler, Allison M J Anacker, Michael H Levin, Nina M Vaswani, Paul J Gresch, Alex G Nackenoff, Noelle C Anastasio, Sonja J Stutz, Kathryn A Cunningham, Jing Wang, Bing Zhang, L Keith Henry, Adele Stewart, Jeremy Veenstra-VanderWeele, Randy D Blakely
Differential gene expression in the prelimbic cortex of WT vs SERT Met172 mice after acute cocaine treatment_FDR_subset0.05
Description:
To elucidate 5-HT transporter (SERT)-specific contributions to cocaine action, we evaluated cocaine effects in the SERT Met172 knock-in mouse, which expresses a SERT coding substitution that eliminates high-affinity cocaine recognition. We measured the effects of SERT Met172 on cocaine antagonism of 5-HT re-uptake using ex vivo synaptosome preparations and in vivo microdialysis. We assessed SERT dependence of cocaine actions behaviourally through acute and chronic locomotor activation, sensitization, conditioned place preference (CPP) and oral cocaine consumption.
Authors:
Linda D Simmler, Allison M J Anacker, Michael H Levin, Nina M Vaswani, Paul J Gresch, Alex G Nackenoff, Noelle C Anastasio, Sonja J Stutz, Kathryn A Cunningham, Jing Wang, Bing Zhang, L Keith Henry, Adele Stewart, Jeremy Veenstra-VanderWeele, Randy D Blakely
Differential gene expression in the nucleus accumbens of WT vs SERT Met172 mice after chronic cocaine treatment_logFC
Description:
To elucidate 5-HT transporter (SERT)-specific contributions to cocaine action, we evaluated cocaine effects in the SERT Met172 knock-in mouse, which expresses a SERT coding substitution that eliminates high-affinity cocaine recognition. We measured the effects of SERT Met172 on cocaine antagonism of 5-HT re-uptake using ex vivo synaptosome preparations and in vivo microdialysis. We assessed SERT dependence of cocaine actions behaviourally through acute and chronic locomotor activation, sensitization, conditioned place preference (CPP) and oral cocaine consumption.
Authors:
Linda D Simmler, Allison M J Anacker, Michael H Levin, Nina M Vaswani, Paul J Gresch, Alex G Nackenoff, Noelle C Anastasio, Sonja J Stutz, Kathryn A Cunningham, Jing Wang, Bing Zhang, L Keith Henry, Adele Stewart, Jeremy Veenstra-VanderWeele, Randy D Blakely
Differential gene expression in the nucleus accumbens of WT vs SERT Met172 mice after chronic cocaine treatment_FDR
Description:
To elucidate 5-HT transporter (SERT)-specific contributions to cocaine action, we evaluated cocaine effects in the SERT Met172 knock-in mouse, which expresses a SERT coding substitution that eliminates high-affinity cocaine recognition. We measured the effects of SERT Met172 on cocaine antagonism of 5-HT re-uptake using ex vivo synaptosome preparations and in vivo microdialysis. We assessed SERT dependence of cocaine actions behaviourally through acute and chronic locomotor activation, sensitization, conditioned place preference (CPP) and oral cocaine consumption.
Authors:
Linda D Simmler, Allison M J Anacker, Michael H Levin, Nina M Vaswani, Paul J Gresch, Alex G Nackenoff, Noelle C Anastasio, Sonja J Stutz, Kathryn A Cunningham, Jing Wang, Bing Zhang, L Keith Henry, Adele Stewart, Jeremy Veenstra-VanderWeele, Randy D Blakely
Differential gene expression in the nucleus accumbens of WT vs SERT Met172 mice after chronic cocaine treatment_FDR_subset0.05
Description:
To elucidate 5-HT transporter (SERT)-specific contributions to cocaine action, we evaluated cocaine effects in the SERT Met172 knock-in mouse, which expresses a SERT coding substitution that eliminates high-affinity cocaine recognition. We measured the effects of SERT Met172 on cocaine antagonism of 5-HT re-uptake using ex vivo synaptosome preparations and in vivo microdialysis. We assessed SERT dependence of cocaine actions behaviourally through acute and chronic locomotor activation, sensitization, conditioned place preference (CPP) and oral cocaine consumption.
Authors:
Linda D Simmler, Allison M J Anacker, Michael H Levin, Nina M Vaswani, Paul J Gresch, Alex G Nackenoff, Noelle C Anastasio, Sonja J Stutz, Kathryn A Cunningham, Jing Wang, Bing Zhang, L Keith Henry, Adele Stewart, Jeremy Veenstra-VanderWeele, Randy D Blakely
Differential gene expression in the prelimbic cortex of WT and SERT Met172 mice after chronic cocaine treatment_logFC
Description:
To elucidate 5-HT transporter (SERT)-specific contributions to cocaine action, we evaluated cocaine effects in the SERT Met172 knock-in mouse, which expresses a SERT coding substitution that eliminates high-affinity cocaine recognition. We measured the effects of SERT Met172 on cocaine antagonism of 5-HT re-uptake using ex vivo synaptosome preparations and in vivo microdialysis. We assessed SERT dependence of cocaine actions behaviourally through acute and chronic locomotor activation, sensitization, conditioned place preference (CPP) and oral cocaine consumption.
Authors:
Linda D Simmler, Allison M J Anacker, Michael H Levin, Nina M Vaswani, Paul J Gresch, Alex G Nackenoff, Noelle C Anastasio, Sonja J Stutz, Kathryn A Cunningham, Jing Wang, Bing Zhang, L Keith Henry, Adele Stewart, Jeremy Veenstra-VanderWeele, Randy D Blakely
Differential gene expression in the prelimbic cortex of WT and SERT Met172 mice after chronic cocaine treatment_FDR
Description:
To elucidate 5-HT transporter (SERT)-specific contributions to cocaine action, we evaluated cocaine effects in the SERT Met172 knock-in mouse, which expresses a SERT coding substitution that eliminates high-affinity cocaine recognition. We measured the effects of SERT Met172 on cocaine antagonism of 5-HT re-uptake using ex vivo synaptosome preparations and in vivo microdialysis. We assessed SERT dependence of cocaine actions behaviourally through acute and chronic locomotor activation, sensitization, conditioned place preference (CPP) and oral cocaine consumption.
Authors:
Linda D Simmler, Allison M J Anacker, Michael H Levin, Nina M Vaswani, Paul J Gresch, Alex G Nackenoff, Noelle C Anastasio, Sonja J Stutz, Kathryn A Cunningham, Jing Wang, Bing Zhang, L Keith Henry, Adele Stewart, Jeremy Veenstra-VanderWeele, Randy D Blakely
Differential gene expression in the prelimbic cortex of WT and SERT Met172 mice after chronic cocaine treatment_FDR_subset0.05
Description:
To elucidate 5-HT transporter (SERT)-specific contributions to cocaine action, we evaluated cocaine effects in the SERT Met172 knock-in mouse, which expresses a SERT coding substitution that eliminates high-affinity cocaine recognition. We measured the effects of SERT Met172 on cocaine antagonism of 5-HT re-uptake using ex vivo synaptosome preparations and in vivo microdialysis. We assessed SERT dependence of cocaine actions behaviourally through acute and chronic locomotor activation, sensitization, conditioned place preference (CPP) and oral cocaine consumption.
Authors:
Linda D Simmler, Allison M J Anacker, Michael H Levin, Nina M Vaswani, Paul J Gresch, Alex G Nackenoff, Noelle C Anastasio, Sonja J Stutz, Kathryn A Cunningham, Jing Wang, Bing Zhang, L Keith Henry, Adele Stewart, Jeremy Veenstra-VanderWeele, Randy D Blakely
Genes associated with nan that interact with the MeSH term '2-methyl-5-HT' (C045918). Incorporates data from 2 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'HTS 466284' (C506615). Incorporates data from 1 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'HT-2 toxin' (C012351). Incorporates data from 7 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Gallus gallus that interact with the MeSH term 'HT-2 toxin' (C012351). Incorporates data from 1 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
QTL associated with radiation-induced apoptosis 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (31984189)
Authors:
Upton AL, Salichon N, Lebrand C, Ravary A, Blakely R, Seif I, Gaspar P
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