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Tier II GS136576 • radiation-induced apoptosis 1 (Rapop1, Published QTL Chr 16)

DESCRIPTION:

QTL associated with radiation-induced apoptosis 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (31984189)

LABEL:

QTL-Rapop1-Mouse-Chr 16

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2024-04-25

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:103275

AUTHORS:

Upton AL, Salichon N, Lebrand C, Ravary A, Blakely R, Seif I, Gaspar P

TITLE:

Excess of serotonin (5-HT) alters the segregation of ispilateral and contralateral retinal projections in monoamine oxidase A knock-out mice: possible role of 5-HT uptake in retinal ganglion cells during development.

JOURNAL:

The Journal of neuroscience : the official journal of the Society for Neuroscience Aug 1999, Vol 19, pp. 7007-24

ABSTRACT:

Retinal ganglion cell (RGCs) project to the ipsilateral and contralateral sides of the brain in the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). Projections from both eyes are initially intermingled until postnatal day 3 (P3) but segregate into eye-specific layers by P8. We report that this segregation does not occur in monoamine oxidase A knock-out mice (MAOA-KO) that have elevated brain levels of serotonin (5-HT) and noradrenaline. The abnormal development of retinal projections can be reversed by inhibiting 5-HT synthesis from P0 to P15. We found that in MAOA-KO mice, 5-HT accumulates in a subpopulation of RGCs and axons during embryonic and early postnatal development. The RGCs do not synthesize 5-HT but reuptake the amine from the extracellular space. In both MAOA-KO and normal mice, high-affinity uptake of 5-HT and serotonin transporter (SERT) immunoreactivity are observed in retinal axons from the optic cup to retinal terminal fields in the SC and dLGN. In the dLGN, transient SERT labeling corresponds predominantly to the ipsilateral retinal projection fields. We show that, in addition to SERT, developing RGCs also transiently express the vesicular monoamine transporter gene VMAT2: thus, retinal axons could store 5-HT in synaptic vesicles and possibly use it as a borrowed neurotransmitter. Finally we show that the 5-HT-1B receptor gene is expressed by RGCs throughout the retina from E15 until adult life. Activation of this receptor is known, from previous studies, to reduce retinotectal activity; thus 5-HT in excess could inhibit activity-dependent segregation mechanisms. A hypothesis is proposed whereby, during normal development, localized SERT expression could confer specific neurotransmission properties on a subset of RGCs and could be important in the fine-tuning of retinal projections. PUBMED: 10436056
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Annotation Information

No sequence read archive data associated with this GeneSet.

Brain (D001921)

Life (D019369)

Projection (D011385)

Extraterrestrial Environment (D005118)

Extracellular Space (D005110)

Retina (D012160)

Retinal Ganglion Cells (D012165)

Mice (D051379)

Eye (D005123)

Research Report (D058028)

Serotonin (D012701)

Serotonin Plasma Membrane Transport Proteins (D050486)

Prejudice (D011287)

Adult (D000328)

Synaptic Vesicles (D013572)

Norepinephrine (D009638)

Ganglion Cysts (D045888)

Mice, Knockout (D018345)

Role (D012380)

Vesicular Monoamine Transport Proteins (D050493)

Cells (D002477)

Monoamine Oxidase (D008995)

Oxidoreductases (D010088)

Neurotransmitter Agents (D018377)

Superior Colliculi (D013477)

Retinaldehyde (D012172)

Axons (D001369)

Transients and Migrants (D014171)

Synaptic Transmission (D009435)

Apoptosis (D017209)

lateral geniculate nucleus (MA:0000869)

retina (MA:0000276)

superior colliculus (MA:0001068)

brain (MA:0000168)

ganglion (MA:0002406)

dorsal lateral geniculate nucleus (MA:0002775)

cell (GO:0005623)

biosynthetic process (GO:0009058)

extracellular region (GO:0005576)

nucleus (GO:0005634)

serotonin uptake (GO:0051610)

extracellular space (GO:0005615)

QTL map (EDAM_data:1860)

Gene List • 448 Genes

Uploaded As	Gene Symbol Gene Symbol Entrez Ensembl Gene UniGene MGI FlyBase WormBase RGD ZFIN	Homology	Score	Priority	LinkOuts	Emphasis

GeneSet Information

Tier II GS136576 • radiation-induced apoptosis 1 (Rapop1, Published QTL Chr 16)

Annotation Information

Gene List • 448 Genes

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GeneSet Information

Tier II GS136576 • radiation-induced apoptosis 1 (Rapop1, Published QTL Chr 16)

Annotation Information

Gene List • 448 Genes

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