Microarray gene expression profiling results of rat-striatum after cocaine self-administration were used to identify co-regulation of certain mRNAs involved in cocaine-induced changes in circadian rhythmicity. This gene set comprises upregulated genes during the 7-day period of hourly cocaine self-infusion.
Authors:
Lynch WJ, Girgenti MJ, Breslin FJ, Newton SS, Taylor JR
Neocortex Gene Expression Correlates for ROTATRAIN_TIME measured in BXD RI Females & Males obtained using GeneNetwork Neocortex ILM6v1.1 (Feb08) RankInv. The ROTATRAIN_TIME measures Mean time on rotarod during training. under the domain Ethanol. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Striatum Gene Expression Correlates for TS_TIME_BELOW measured in BXD RI Females & Males obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The TS_TIME_BELOW measures Time below threshold under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Hippocampus Gene Expression Correlates for LM_ALT_CONTEXT measured in BXD RI Females obtained using GeneNetwork Hippocampus Consortium M430v2 (Jun06) RMA. The LM_ALT_CONTEXT measures Activity in altered context in fear conditioning apparatus under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Striatum Gene Expression Correlates for LM_CONTEXT_ACTIVITY measured in BXD RI Females obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The LM_CONTEXT_ACTIVITY measures Contextual activity in fear conditioning apparatus under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Cerebellum Gene Expression Correlates for SPD_TIMEDOWEL30SEC measured in BXD RI Females & Males obtained using SJUT Cerebellum mRNA M430 (Mar05) RMA. The SPD_TIMEDOWEL30SEC measures Dowel Test - Time 30 Sec under the domain Porsolt. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Cerebellum Gene Expression Correlates for SPD_TIMEDOWEL30SEC measured in BXD RI Males obtained using SJUT Cerebellum mRNA M430 (Mar05) RMA. The SPD_TIMEDOWEL30SEC measures Dowel Test - Time 30 Sec under the domain Porsolt. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
cocaine related behavior 16 (Cocrb16) spans 126.65 - 156 Mbp (NCBI Build 37) on Chr 4. Obtained from MGI (http://www.informatics.jax.org) by searching for QTLs containing the keyword "Cocaine".
alcohol preference 3 QTL 124.51 - 174.51 Mbp (NCBI Build 37) on Chr4. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL for cocaine related behavior on Chr4 at 34M15-SP6 (151.65 Mbp , Build 37)
Description:
cocaine related behavior spans 126.65 - 176.65 Mbp (NCBI Build 37) on Chr4. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL for ethanol conditioned taste aversion on Chr4 at D4Ncvs25 (151.65 Mbp , Build 37)
Description:
ethanol conditioned taste aversion spans 126.65 - 176.65 Mbp (NCBI Build 37) on Chr4. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL for METH responses for climbing on Chr4 at Sac (151.65 Mbp , Build 37)
Description:
METH responses for climbing spans 126.65 - 176.65 Mbp (NCBI Build 37) on Chr4. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
Chronic cocaine - D1 receptor mutant vs. Wildtype DNA microarray Gene expression differences between mutant and wildtype D1 receptor mutant and wild-type mice were injected twice daily at 11:00 and 16:00 for 7 days with 20 mg / kg of cocaine. Gene expression differences 24 h after cocaine withdrawal. p<0.05 was considered as significant. Based on this criterion, we used a cutoff of at least a 1.2-fold difference in expression for further studies. (NIF Method ID 68)
Authors:
Zhang D, Zhang L, Tang Y, Zhang Q, Lou D, Sharp FR, Zhang J, Xu M
Chronic cocaine - Cocaine vs. Saline DNA microarray Change in gene expression Five rats were trained to self-administer cocaine infusions (1.5 mg / kg) during daily sessions. Once rats acquired cocaine self-administration (five consecutive sessions in which rats earned all 20 infusions that were available), cocaine infusions (1.5 mg / kg) were available in discrete 10-min trials 24-hr per day (4 trials / hr). Each discrete trial was initiated by the extension of the left lever into the chamber. Each response on this lever during a 10-minute discrete trial produced an infu Genespring 7.0 A gene was considered to be expressed if its signal intensity was a minimum of twice the background in at least four of the five replicates. Upregulated genes were defined as having an average expression ratio of >1.4, and the downregulated genes were defined as having an average expression ratio of <0.7. A gene was considered to be significantly regulated if the t-test p-value was < 0.05 with the false discovery rate (FDR) as the multiple testing correction. (NIF Method ID 182)
Authors:
Lynch WJ, Girgenti MJ, Breslin FJ, Newton SS, Taylor JR
Genes associated with Homo sapiens that interact with the MeSH term 'entinostat' (C118739). Incorporates data from 11 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term '(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine' (C516138). Incorporates data from 3 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'vorinostat' (C111237). Incorporates data from 13 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'Tretinoin' (D014212). Incorporates data from 1 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'p-Chloromercuribenzoic Acid' (D020245). Incorporates data from 96 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Ovis aries that interact with the MeSH term 'Progesterone' (D011374). Incorporates data from 3 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
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