GeneSet Information

Tier III GS14912 • Upregulated genes in rat-striatum after cocaine self-adminstration

DESCRIPTION:

Microarray gene expression profiling results of rat-striatum after cocaine self-administration were used to identify co-regulation of certain mRNAs involved in cocaine-induced changes in circadian rhythmicity. This gene set comprises upregulated genes during the 7-day period of hourly cocaine self-infusion.

LABEL:

Rat UpRegCocaine

SCORE TYPE:

P-Value

DATE ADDED:

2009-01-20

DATE UPDATED:

2021-07-20

SPECIES:

AUTHORS:

Lynch WJ, Girgenti MJ, Breslin FJ, Newton SS, Taylor JR

TITLE:

Gene profiling the response to repeated cocaine self-administration in dorsal striatum: a focus on circadian genes.

JOURNAL:

Brain research Jun 2008, Vol 1213, pp. 166-77

ABSTRACT:

Alterations in gene expression in the dorsal striatum caused by chronic cocaine exposure have been implicated in the long-term behavioral changes associated with cocaine addiction. To gain further insight into the molecular alterations that occur as a result of cocaine self-administration, we conducted a microarray analysis of gene expression followed by bioinformatic gene network analysis that allowed us to identify adaptations at the level of gene expression as well as into interconnected networks. Changes in gene expression were examined in the dorsal striatum of rats 1 day after they had self-administered cocaine for 7 days under a 24-h access, discrete trial paradigm (averaging 98 mg/kg/day). Here we report the regulation of the circadian genes Clock, Bmal1, Cryptochrome1, Period2, as well as several genes that are regulated by/associated with the circadian system (i.e., early growth response 1, dynorphin). We also observed regulation of other relevant genes (i.e., Nur77, beta catenin). These changes were then linked to curated pathways and formulated networks which identified circadian rhythm processes as affected by cocaine self-administration. These data strongly suggest involvement of circadian-associated genes in the brain\'s response to cocaine and may contribute to an understanding of addictive behavior including disruptions in sleep and circadian rhythmicity. PUBMED: 18452895
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Annotation Information

No sequence read archive data associated with this GeneSet.


Growth (D006128)
Social Control, Formal (D012926)
Brain (D001921)
Self Administration (D012646)
Animals (D000818)
Behavior (D001519)
Corpus Striatum (D003342)
Behavior, Addictive (D016739)
Circadian Rhythm (D002940)
Gene Regulatory Networks (D053263)
Gene Expression Profiling (D020869)
Comprehension (D032882)
Research Report (D058028)
Behavior, Animal (D001522)
Periodicity (D010507)
Microarray Analysis (D046228)
Dopamine Uptake Inhibitors (D018765)
Time Factors (D013997)
Rats (D051381)
Cocaine-Related Disorders (D019970)
Oligonucleotide Array Sequence Analysis (D020411)
Cocaine (D003042)
Set (Psychology) (D012718)
Sleep (D012890)
Rats, Sprague-Dawley (D017207)
striatum (MA:0000891)
dorsal striatum (MA:0002971)
brain (MA:0000168)
addiction (MP:0002555)
sleep (GO:0030431)
response to cocaine (GO:0042220)
growth (GO:0040007)
circadian rhythm (GO:0007623)
gene expression (GO:0010467)
behavior (GO:0007610)
Trait (VT:0000001)
response to cocaine trait (VT:0010718)
response to addictive substance trait (VT:0010488)
response to xenobiotic stimulus trait (VT:0010487)
organism trait (VT:0010454)

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Supported by NIH R01 AA18776 jointly funded by NIAAA and NIDA, and JAX Center for Precision Genetics NIH U54 OD 020351