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QTL associated with catalepsy susceptibility 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (119618032)
Authors:
Kulikov AV, Bazovkina DV, Kondaurova EM, Popova NK
QTL associated with collagen induced arthritis 10. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (102207023)
Authors:
Glant TT, Adarichev VA, Nesterovitch AB, Szanto S, Oswald JP, Jacobs JJ, Firneisz G, Zhang J, Finnegan A, Mikecz K
QTL associated with directional asymmetry QTL 9. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (119863504)
QTL associated with ethanol induced low dose activation 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (111229752)
QTL associated with granulosa cell tumorigenesis 9. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (112690498)
Authors:
Dorward AM, Shultz KL, Horton LG, Li R, Churchill GA, Beamer WG
QTL associated with wound healing/regeneration 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (111528941)
Authors:
Heber-Katz E, Chen P, Clark L, Zhang XM, Troutman S, Blankenhorn EP
QTL associated with postnatal body weight growth 17. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (101509507)
QTL associated with postnatal body weight growth 6. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (101509507)
QTL associated with reduced platelet aggregation. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (113155804)
QTL associated with salmonella enteritidis susceptibility 10. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (100373415)
QTL associated with TallyHo associated non-insulin dependent diabetes mellitus 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (109618963)
QTL associated with ventral midbrain iron content 7. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (113551966)
Authors:
Jones BC, Reed CL, Hitzemann R, Wiesinger JA, McCarthy KA, Buwen JP, Beard JL
The current study used two inbred mouse strains, C57BL/6 J and A/J, to investigate the genetics of behavioral responses to fentanyl. Mice were tested for conditioned place preference and fentanyl-induced locomotor activity. C57BL/6J mice formed a conditioned place preference to fentanyl injections and fentanyl increased their activity. Neither effect was noted in A/J mice. We conducted RNA-sequencing on the nucleus accumbens of mice used for fentanyl-induced locomotor activity. Surprisingly, we noted few differentially expressed genes using treatment as the main factor. However many genes differed between strains.
Authors:
Samuel J Harp, Mariangela Martini, Will Rosenow, Larry D Mesner, Hugh Johnson, Charles R Farber, Emilie F Rissman
Differential gene expression in nucleus accumbens somatostatin interneurons_cocaine_mice_pvalue
Description:
To characterize transcriptional alterations that cocaine induces in these cells, we perform cell type-specific RNA-sequencing on FACS-isolated nuclei of somatostatin interneurons and identified 1100 DETs enriched for processes related to neural plasticity. To profile the entire (non poly-A selected) transcriptome of NAc somatostatin interneurons, we generated a transgenic reporter line (SST-TLG498 mice) to label the nuclei of these cells with a modified form of EGFP that is retained in the nuclear membrane (EGFP-F)22, enabling their isolation from NAc dissections using FACS. We succeeded in FACS-isolating nuclei suitable for RNA-sequencing from individual SST-TLG498 mice. We proceeded with differential expression analysis of the RNA-sequencing data to identify differentially expressed transcripts (DETs) in NAc somatostatin interneurons in response to repeated cocaine exposure: 778 transcripts were upregulated by cocaine and 322 were downregulated.
Authors:
Efrain A Ribeiro, Marine Salery, Joseph R Scarpa, Erin S Calipari, Peter J Hamilton, Stacy M Ku, Hope Kronman, Immanuel Purushothaman, Barbara Juarez, Mitra Heshmati, Marie Doyle, Casey Lardner, Dominicka Burek, Ana Strat, Stephen Pirpinias, Ezekiell Mouzon, Ming-Hu Han, Rachael L Neve, Rosemary C Bagot, Andrew Kasarskis, Ja Wook Koo, Eric J Nestler