DESCRIPTION:

QTL associated with catalepsy susceptibility 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (119618032)

LABEL:

QTL-Catys1-Mouse-Chr 13

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2024-04-25

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:3618862

AUTHORS:

Kulikov AV, Bazovkina DV, Kondaurova EM, Popova NK

TITLE:

Genetic structure of hereditary catalepsy in mice.

JOURNAL:

Genes, brain, and behavior Jun 2008, Vol 7, pp. 506-12

ABSTRACT:

Catalepsy or pronounced freezing is a natural passive defense strategy in animals and a syndrome of some mental disorders in human. Hereditary catalepsy was shown to be associated with depressive-like features in rats and mice. The loci underlying the difference in predisposition to catalepsy between catalepsy-prone CBA/lacJ and catalepsy-resistant AKR/J mice were mapped using congenic line and selective breeding approaches. Three congenic mouse lines (AKR.CBA-D13Mit76C, AKR.CBA-D13Mit76A and AKR.CBA-D13Mit78) carrying the 59- to 70-, 61- to 70- and 71- to 75-cm fragments of chromosome 13 transferred from the CBA to the AKR genome were created by nine successive backcrossing of (CBA x AKR)F(1) on AKR strain. Because catalepsy was found only in the AKR.CBA-D13Mit76C and AKR.CBA-D13Mit76A mice, the major gene of catalepsy was mapped on the fragment of 61-70 cm. Selective breeding of the (CBA x (CBA x AKR))BC backcross generation for high predisposition to catalepsy showed numerous genome-wide distributed CBA-derived alleles as well as the AKR-derived alleles mapped on chromosome 17 and on the proximal parts of chromosomes 10 and 19 that increased the cataleptogenic effect of the major gene. PUBMED: 18194468
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