Ethanol Induced Hypothermia Chr# 7 rs13479153(25722935) with right flanking marker rs3700068(4187548) and left marker rs3716088(140189839). This was mapped in 300 + (b6x129)F2 mice.
Rotarod Baseline Chr# 7 rs4226783(100081465) with right flanking marker rs8260975(53682778) and left marker rs13479506 (131822778). This was mapped in 300 + (b6x129)F2 mice.
Average rotarod training latency Chr# 7 mCV23423763(68111945) with right flanking marker rs3700068(4187548) and left marker rs3663988(146505067). This was mapped in 300 + (b6x129)F2 mice.
In 3-month-old C57BL/6J mice, 2229 genes (1980 up-regulated vs. 449 down-regulated) were differentially expressed 1 hour after fear conditioning when compared with the age-matched control group in the hippocampus. False Discovery rate (FDR) < 5%, fold change log2 ≥ 1.
Authors:
Peleg S, Sananbenesi F, Zovoilis A, Burkhardt S, Bahari-Javan S, Agis-Balboa RC, Cota P, Wittnam JL, Gogol-Doering A, Opitz L, Salinas-Riester G, Dettenhofer M, Kang H, Farinelli L, Chen W, Fischer A
In 3-month-old C57BL/6 mice, 1539 differentially expressed genes (1362 up-regulated vs. 177 down-regulated) were specific for associative learning (learning-regulated genes)in the hippocampus using fear conditioning. False Discovery rate (FDR) < 5%, fold change log2 ≥ 1
Authors:
Peleg S, Sananbenesi F, Zovoilis A, Burkhardt S, Bahari-Javan S, Agis-Balboa RC, Cota P, Wittnam JL, Gogol-Doering A, Opitz L, Salinas-Riester G, Dettenhofer M, Kang H, Farinelli L, Chen W, Fischer A
Transcriptome sequencing from the SCNs of mice (C57BL/6J) entrained for 4 weeks to 22 h and 24 h d maintained for a week in darkness, and then killed at CT4 for each mouse. Supplementary table 3: List of the genomic regions hypomethylated in ST and Score.
Authors:
Azzi A, Dallmann R, Casserly A, Rehrauer H, Patrignani A, Maier B, Kramer A, Brown SA
The current study used two inbred mouse strains, C57BL/6 J and A/J, to investigate the genetics of behavioral responses to fentanyl. Mice were tested for conditioned place preference and fentanyl-induced locomotor activity. C57BL/6J mice formed a conditioned place preference to fentanyl injections and fentanyl increased their activity. Neither effect was noted in A/J mice. We conducted RNA-sequencing on the nucleus accumbens of mice used for fentanyl-induced locomotor activity. Surprisingly, we noted few differentially expressed genes using treatment as the main factor. However many genes differed between strains.
Authors:
Samuel J Harp, Mariangela Martini, Will Rosenow, Larry D Mesner, Hugh Johnson, Charles R Farber, Emilie F Rissman
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