GeneSet Information

Tier III GS137398 • Differential expression of fear associative learning in the hippocampus with C57BL/6.

DESCRIPTION:

In 3-month-old C57BL/6 mice, 1539 differentially expressed genes (1362 up-regulated vs. 177 down-regulated) were specific for associative learning (learning-regulated genes)in the hippocampus using fear conditioning. False Discovery rate (FDR) < 5%, fold change log2 ≥ 1

LABEL:

Dif Exp-Fear/Learning-Hippo

SCORE TYPE:

Correlation

DATE ADDED:

None

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Peleg S, Sananbenesi F, Zovoilis A, Burkhardt S, Bahari-Javan S, Agis-Balboa RC, Cota P, Wittnam JL, Gogol-Doering A, Opitz L, Salinas-Riester G, Dettenhofer M, Kang H, Farinelli L, Chen W, Fischer A

TITLE:

Altered histone acetylation is associated with age-dependent memory impairment in mice.

JOURNAL:

Science (New York, N.Y.) May 2010, Vol 328, pp. 753-6

ABSTRACT:

As the human life span increases, the number of people suffering from cognitive decline is rising dramatically. The mechanisms underlying age-associated memory impairment are, however, not understood. Here we show that memory disturbances in the aging brain of the mouse are associated with altered hippocampal chromatin plasticity. During learning, aged mice display a specific deregulation of histone H4 lysine 12 (H4K12) acetylation and fail to initiate a hippocampal gene expression program associated with memory consolidation. Restoration of physiological H4K12 acetylation reinstates the expression of learning-induced genes and leads to the recovery of cognitive abilities. Our data suggest that deregulated H4K12 acetylation may represent an early biomarker of an impaired genome-environment interaction in the aging mouse brain. PUBMED: 20448184
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Annotation Information

No sequence read archive data associated with this GeneSet.


Brain (D001921)
Aptitude (D001076)
Life (D019369)
Memory (D008568)
Humans (D006801)
Aging (D000375)
Mice (D051379)
Fear (D005239)
Conditioning (Psychology) (D003213)
Acetylation (D000107)
Learning (D007858)
Lysine (D008239)
Stress, Psychological (D013315)
Aged (D000368)
Chromatin (D002843)
Histones (D006657)
Hippocampus (D006624)
brain (MA:0000168)
hippocampus (MA:0000191)
chromatin (GO:0000785)
aging (GO:0007568)
associative learning (GO:0008306)
histone acetylation (GO:0016573)
gene expression (GO:0010467)
learning (GO:0007612)
memory (GO:0007613)

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Supported by NIH R01 AA18776 jointly funded by NIAAA and NIDA, and JAX Center for Precision Genetics NIH U54 OD 020351