Heterozygote mice from a hybrid cross of C57BL/6J and FVB/NJ had heightened EtOH consumption, preference or blood EtOH concentration compared to either homozygous groups. The magnitude of dominant deviation on Chr. 11, as noted in Fig. 9, was measured after a drinking in the dark paradigm, 24hr two-bottle-choice and subsequent blood ethanol concentration measurement.
Authors:
Phillips TJ, Reed C, Burkhart-Kasch S, Li N, Hitzemann R, Yu CH, Brown LL, Helms ML, Crabbe JC, Belknap JK
cocaine related behavior 11 (Cocrb11) spans 0 - 27.768945 Mbp (NCBI Build 37) on Chr 11. Obtained from MGI (http://www.informatics.jax.org) by searching for QTLs containing the keyword .
QTL for differences in cocaine responsiveness on Chr11 at D11M!t2 (8.35 Mbp , Build 37)
Description:
differences in cocaine responsiveness spans 0.00 - 33.35 Mbp (NCBI Build 37) on Chr11. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL for cocaine related behavior on Chr11 at Glns-ps1 (18.69 Mbp , Build 37)
Description:
cocaine related behavior spans 0.00 - 43.69 Mbp (NCBI Build 37) on Chr11. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL for chronic alcohol withdrawal severity on Chr11 at D11Mit340 (18.69 Mbp , Build 37)
Description:
chronic alcohol withdrawal severity spans 0.00 - 43.69 Mbp (NCBI Build 37) on Chr11. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
Authors:
Bergeson SE, Kyle Warren R, Crabbe JC, Metten P, Gene Erwin V, Belknap JK
QTL for nicotine sensitivity on Chr11 at D11Mit82 (21.63 Mbp , Build 37)
Description:
nicotine sensitivity spans 0.00 - 46.63 Mbp (NCBI Build 37) on Chr11. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
In 3-month-old C57BL/6J mice, 2229 genes (1980 up-regulated vs. 449 down-regulated) were differentially expressed 1 hour after fear conditioning when compared with the age-matched control group in the hippocampus. False Discovery rate (FDR) < 5%, fold change log2 ≥ 1.
Authors:
Peleg S, Sananbenesi F, Zovoilis A, Burkhardt S, Bahari-Javan S, Agis-Balboa RC, Cota P, Wittnam JL, Gogol-Doering A, Opitz L, Salinas-Riester G, Dettenhofer M, Kang H, Farinelli L, Chen W, Fischer A
In 3-month-old C57BL/6 mice, 1539 differentially expressed genes (1362 up-regulated vs. 177 down-regulated) were specific for associative learning (learning-regulated genes)in the hippocampus using fear conditioning. False Discovery rate (FDR) < 5%, fold change log2 ≥ 1
Authors:
Peleg S, Sananbenesi F, Zovoilis A, Burkhardt S, Bahari-Javan S, Agis-Balboa RC, Cota P, Wittnam JL, Gogol-Doering A, Opitz L, Salinas-Riester G, Dettenhofer M, Kang H, Farinelli L, Chen W, Fischer A
Genes that are differentially expressed in response to over expressing MECP2 (causes anxiety phenotype) in the amygdala. Statistics reported as fold change.
Authors:
Samaco RC, Mandel-Brehm C, McGraw CM, Shaw CA, McGill BE, Zoghbi HY
Genes with particular expression in the Primary somatosensory area, mouth, layer 6b. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Primary somatosensory area, trunk, layer 6a. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Induseum griseum. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Posterior parietal association areas. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Intergeniculate leaflet of the lateral geniculate complex. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Entorhinal area, lateral part, layer 6a. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Anterior cingulate area. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Primary visual area, layer 6a. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Gustatory areas, layer 1. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Anterior cingulate area, dorsal part. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the posteromedial visual area, layer 2/3. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Infralimbic area. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Anterior cingulate area, ventral part. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Entorhinal area, lateral part, layer 3. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Nucleus accumbens. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Frontal pole, layer 1. Data represent fold expression difference in structure versus grey matter average expression.
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