QTL Associated with Joint/bone inflammation. On Chromosome 4 with a LOD score= 2.3, p-value =. From a(n) F2 of LEWxF344
Authors:
Wilder RL, Griffiths MM, Remmers EF, Cannon GW, Caspi RR, Kawahito Y, Gulko PS, Longman RE, Dracheva SV, Du Y, Sun SH, Wang J, Shepard JS, Joe B, Ge L, Chen S, Chang L, Hoffman J, Silver PB, Reese VR
We investigated the role of microglia in a mouse model of alcohol dependence using a colony stimulating factor 1 receptor inhibitor (PLX5622) to deplete microglia and a chronic intermittent ethanol vapor two-bottle choice drinking procedure. Additionally, we examined anxiety-like behavior during withdrawal. We then analyzed synaptic neuroadaptations in the central nucleus of the amygdala (CeA) and gene expression changes in the medial prefrontal cortex (mPFC) and CeA from the same animals used for behavioral studies.
Alcohol dependence in the medial prefrontal cortex q-value
Description:
We investigated the role of microglia in a mouse model of alcohol dependence using a colony stimulating factor 1 receptor inhibitor (PLX5622) to deplete microglia and a chronic intermittent ethanol vapor two-bottle choice drinking procedure. Additionally, we examined anxiety-like behavior during withdrawal. We then analyzed synaptic neuroadaptations in the central nucleus of the amygdala (CeA) and gene expression changes in the medial prefrontal cortex (mPFC) and CeA from the same animals used for behavioral studies.
Alcohol Microglia depletion in the medial prefrontal cortex q-value
Description:
dependence using a colony stimulating factor 1 receptor inhibitor (PLX5622) to deplete microglia and a chronic intermittent ethanol vapor two-bottle choice drinking procedure. Additionally, we examined anxiety-like behavior during withdrawal. We then analyzed synaptic neuroadaptations in the central nucleus of the amygdala (CeA) and gene expression changes in the medial prefrontal cortex (mPFC) and CeA from the same animals used for behavioral studies.
Alcohol interaction of dependence and MG depletion the medial prefrontal cortex q-value
Description:
We investigated the role of microglia in a mouse model of alcohol dependence using a colony stimulating factor 1 receptor inhibitor (PLX5622) to deplete microglia and a chronic intermittent ethanol vapor two-bottle choice drinking procedure. Additionally, we examined anxiety-like behavior during withdrawal. We then analyzed synaptic neuroadaptations in the central nucleus of the amygdala (CeA) and gene expression changes in the medial prefrontal cortex (mPFC) and CeA from the same animals used for behavioral studies.
QTL associated with p-glycoprotein positive CD4 T cell subset 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (45152335)
QTL associated with vertebral trabecular bone trait 15. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (45159272)
Authors:
Bouxsein ML, Uchiyama T, Rosen CJ, Shultz KL, Donahue LR, Turner CH, Sen S, Churchill GA, Mller R, Beamer WG
QTL for ethanol withdrawal on Chr13 at D13Ncvs35 (71.29 Mbp , Build 37)
Description:
ethanol withdrawal spans 46.29 - 96.29 Mbp (NCBI Build 37) on Chr13. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL associated with spontaneous crescentic glomerulonephritis QTL 5. The confidence interval is Chr13:35968794-96872609 bp,+strand
Authors:
Hamano Y, Tsukamoto K, Abe M, Sun GD, Zhang D, Fujii H, Matsuoka S, Tanaka M, Ishida-Okawara A, Tachikawa H, Nishimura H, Tokunaka K, Hirose S, Suzuki K
QTL associated with Angiostrongylus costaricensis nematode susceptibility 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (53042863)
QTL associated with Avp transcript abundance QTL 3. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (85473357)
QTL associated with castaneus 10 week body weight 4. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (72374309)
QTL associated with cystic fibrosis body weight 5. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (55673906)
QTL associated with cocaine induced activation 11. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (54579545)
QTL associated with "cerebellum pattern fissures, declival 5". This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (56582797)
QTL associated with circadian period of locomotor activity 11. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (55673906)
Authors:
Hofstetter JR, Trofatter JA, Kernek KL, Nurnberger JI, Mayeda AR
QTL associated with Crh transcript abundance QTL 3. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (56786703)
QTL associated with delta power in slow-wave sleep 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (85473357)
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