GeneSet Information

Tier IV GS273275 • preBötzinger complex neurons

DESCRIPTION:

preBötzinger complex neurone, reporter positive cell expression. Average of 3 with values greater than 0. From GEO GSM2679440 normalized files.

LABEL:

preBötzinger complex neurones

SCORE TYPE:

Effect

DATE ADDED:

2017-11-02

DATE UPDATED:

2021-04-19

SPECIES:

AUTHORS:

Hayes JA, Kottick A, Picardo MCD, Halleran AD, Smith RD, Smith GD, Saha MS, Del Negro CA

TITLE:

None

JOURNAL:

Scientific reports Aug 2017, Vol 7, pp. 8669

ABSTRACT:

We sequenced the transcriptome of brainstem interneurons in the specialized respiratory rhythmogenic site dubbed preBötzinger Complex (preBötC) from newborn mice. To distinguish molecular characteristics of the core oscillator we compared preBötC neurons derived from Dbx1-expressing progenitors that are respiratory rhythmogenic to neighbouring non-Dbx1-derived neurons, which support other respiratory and non-respiratory functions. Results in three categories are particularly salient. First, Dbx1 preBötC neurons express κ-opioid receptors in addition to μ-opioid receptors that heretofore have been associated with opiate respiratory depression, which may have clinical applications. Second, Dbx1 preBötC neurons express the hypoxia-inducible transcription factor Hif1a at levels three-times higher than non-Dbx1 neurons, which links core rhythmogenic microcircuits to O2-related chemosensation for the first time. Third, we detected a suite of transcription factors including Hoxa4 whose expression pattern may define the rostral preBötC border, Pbx3 that may influence ipsilateral connectivity, and Pax8 that may pertain to a ventrally-derived subset of Dbx1 preBötC neurons. These data establish the transcriptomic signature of the core respiratory oscillator at a perinatal stage of development. PUBMED: 28819234
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