Mouse dorsal striatum RNA levels correlated to oxycodone SA levels
Description:
6 genes differentially expressed in the 11-week old C57BL/6J male mouse dorsal striatum correlating to levels of oxycodone self-administration based on RNA-seq data. Values presented are p-adjusted values. Data were taken from Table 4. GEO accession: GSE113948.
Authors:
Yong Zhang, Yupu Liang, Matthew Randesi, Vadim Yuferov, Connie Zhao, Mary Jeanne Kreek
32 genes differentially expressed in the 11-week old C57BL/6J male mouse ventral striatum following oxycodone self-administration based on RNA-seq data. The first five genes in this GeneSet are ones displaying experiment-wise significant changes in RNA levels; the remaining show point-wise significance. Data were taken from Table 1. Values presented are p-adjusted values.
GEO accession: GSE113948.
Authors:
Yong Zhang, Yupu Liang, Matthew Randesi, Vadim Yuferov, Connie Zhao, Mary Jeanne Kreek
7 genes differentially expressed in the 11-week old C57BL/6J male mouse dorsal striatum following oxycodone self-administration based on RNA-seq data. Values presented are p-adjusted values. Data were taken from Table 2. GEO accession: GSE113948.
Authors:
Yong Zhang, Yupu Liang, Matthew Randesi, Vadim Yuferov, Connie Zhao, Mary Jeanne Kreek
Mouse ventral striatum RNA levels correlated to oxycodone SA levels
Description:
3 genes differentially expressed in the 11-week old C57BL/6J male mouse ventral striatum correlated to levels of oxycodone self-administration based on RNA-seq data. Values presented are p-adjusted values. Data are from Table 3. GEO accession: GSE113948.
Authors:
Yong Zhang, Yupu Liang, Matthew Randesi, Vadim Yuferov, Connie Zhao, Mary Jeanne Kreek
Statistical analysis of the 224 reward-related genes differentially expressed in the 11-week old C57BL/6J male mouse ventral striatum following oxycodone self-administration based on RNA-seq data. Values presented are p-adjusted values. Note: genes with a p-adjusted value of "NA" were excluded. Data were take from Table 6. GEO accession: GSE113948.
Authors:
Yong Zhang, Yupu Liang, Matthew Randesi, Vadim Yuferov, Connie Zhao, Mary Jeanne Kreek
Genes that are suppressed by THC in total lymph node (LN) cells in C57BL/6J mice. Gene expression was evaluated via RNA-seq. Values presented are "1" for effect presence. Data taken from Supplemental Data 1.
Authors:
Xiaoming Yang, Marpe Bam, Prakash S Nagarkatti, Mitzi Nagarkatti
Genes that are induced by THC in total lymph node (LN) cells in C57BL/6J mice. Gene expression was evaluated via RNA-seq. Values presented are "1" for effect presence. Data taken from Supplemental Data 1.
Authors:
Xiaoming Yang, Marpe Bam, Prakash S Nagarkatti, Mitzi Nagarkatti
Genes that are suppressed by THC in CD4 cells in C57BL/6J mice. Gene expression was evaluated via RNA-seq. Values presented are "1" for effect presence. Data taken from Supplemental Data 1.
Authors:
Xiaoming Yang, Marpe Bam, Prakash S Nagarkatti, Mitzi Nagarkatti
Genes that are induced by THC in CD4 cells in C57BL/6J mice. Gene expression was evaluated via RNA-seq. Values presented are "1" for effect presence. Data taken from Supplemental Data 1.
Authors:
Xiaoming Yang, Marpe Bam, Prakash S Nagarkatti, Mitzi Nagarkatti
Genes that are suppressed by THC in both CD4+ cells and total lymph node (LN) cells in C57BL/6J mice. Gene expression was evaluated via RNA-seq. Values presented are "1" for effect presence. Data taken from Supplemental Data 1.
Authors:
Xiaoming Yang, Marpe Bam, Prakash S Nagarkatti, Mitzi Nagarkatti
Genes that are induced by THC in both CD4+ cells and total lymph node (LN) cells in C57BL/6J mice. Gene expression was evaluated via RNA-seq. Values presented are "1" for effect presence. Data taken from Supplemental Data 1.
Authors:
Xiaoming Yang, Marpe Bam, Prakash S Nagarkatti, Mitzi Nagarkatti
59 genes associated with core antiviral effects in humans. Peripheral blood mononuclear cells (PBMCs) from 7 opioid-dependent and 7 non-dependent human subjects were isolated from blood samples and analyzed via scRNA-seq. Data taken from Supplementary Table 1. Values presented are "1" to represent presence. Cell-hashing scRNA-seq data available at GEO (accession: GSE128879)
Authors:
Tanya T Karagiannis, John P Cleary, Busra Gok, Andrew J Henderson, Nicholas G Martin, Masanao Yajima, Elliot C Nelson, Christine S Cheng
52 genes associated with peaked inflammatory effects in humans. Peripheral blood mononuclear cells (PBMCs) from 7 opioid-dependent and 7 non-dependent human subjects were isolated from blood samples and analyzed via scRNA-seq. Data taken from Supplementary Table 1. Values presented are "1" to represent presence. Cell-hashing scRNA-seq data available at GEO (accession: GSE128879)
Authors:
Tanya T Karagiannis, John P Cleary, Busra Gok, Andrew J Henderson, Nicholas G Martin, Masanao Yajima, Elliot C Nelson, Christine S Cheng
49 genes associated with sustained inflammatory effects in humans. Peripheral blood mononuclear cells (PBMCs) from 7 opioid-dependent and 7 non-dependent human subjects were isolated from blood samples and analyzed via scRNA-seq. Data taken from Supplementary Table 1. Values presented are "1" to represent presence. Cell-hashing scRNA-seq data available at GEO (accession: GSE128879).
Authors:
Tanya T Karagiannis, John P Cleary, Busra Gok, Andrew J Henderson, Nicholas G Martin, Masanao Yajima, Elliot C Nelson, Christine S Cheng
Analysis using RNA-seq of FACS-purified oligodendrocytes revealed a large cohort of morphine-regulated genes. In addition, to investigate cell-type-specific opioid responses, we performed single-cell RNA sequencing (scRNA-seq) of the nucleus accumbens of mice following acute morphine treatment. Differential expression analysis uncovered unique morphine-dependent transcriptional responses by oligodendrocytes and astrocytes.
Authors:
Denis Avey, Sumithra Sankararaman, Aldrin K Y Yim, Ruteja Barve, Jeffrey Milbrandt, Robi D Mitra
Analysis using RNA-seq of FACS-purified oligodendrocytes revealed a large cohort of morphine-regulated genes. In addition, to investigate cell-type-specific opioid responses, we performed single-cell RNA sequencing (scRNA-seq) of the nucleus accumbens of mice following acute morphine treatment. Differential expression analysis uncovered unique morphine-dependent transcriptional responses by oligodendrocytes and astrocytes.
Authors:
Denis Avey, Sumithra Sankararaman, Aldrin K Y Yim, Ruteja Barve, Jeffrey Milbrandt, Robi D Mitra
H3K4me3 CHiP Seq data for alcohol dependence. Gene Symbol and p-value (unadjusted). Samples were from twenty-three hippocampi from eight people with a history of alcohol user, seven people with a history of cocaine use, and eight matched control subjects.
H3K4me3 CHiP Seq data for Hippocampus from post-mortem sample of people with a history of cocaine use. Gene Symbol and p-value (unadjusted). Samples were from twenty-three hippocampi from eight people with a history of alcohol use, seven people with a history of cocaine use, and eight matched control subjects.
Intraperitoneal injection of 20mg/kg of cocaine was administered to C57BL/6J mice for one day (acute exposure) or for seven consecutive days (chronic exposure). RNA-seq was performed on the nucleus accumbens of each animal to properly characterize the transcriptomes. The quality of the data was assessed using the RNA-SeQC package. Approximately 95% of the mapped reads were intragenic, while approximately 81% were exonic.
Authors:
Feng J, Wilkinson M, Liu X, Purushothaman I, Ferguson D, Vialou V, Maze I, Shao N, Kennedy P, Koo J, Dias C, Laitman B, Stockman V, LaPlant Q, Cahill ME, Nestler EJ, Shen L
Intraperitoneal injection of 20mg/kg of cocaine was administered to C57BL/6J mice for one day (acute exposure) or for seven consecutive days (chronic exposure). RNA-seq was performed on the nucleus accumbens (NAc) of each animal to properly characterize the transcriptomes. The quality of the data was assessed using the RNA-SeQC package. 55 genes were identified to be differentially expressed within the NAc between the acute and chronic exposure groups, with only 4 genes overlapping.
Authors:
Feng J, Wilkinson M, Liu X, Purushothaman I, Ferguson D, Vialou V, Maze I, Shao N, Kennedy P, Koo J, Dias C, Laitman B, Stockman V, LaPlant Q, Cahill ME, Nestler EJ, Shen L
5 genes that are differentially expressed in the nucleus accumbens (NAc) of adult male H3.3-HA mice following 19 d of cocaine-self administration. Gene expression was evaluated via RNA-seq. Values presented are adjusted p-values. Data taken from Table 1.
Authors:
Mathieu E Wimmer, Bruno Fant, Sarah E Swinford-Jackson, Alexander Testino, Duncan Van Nest, Ted Abel, R Christopher Pierce
59 differentially expressed genes in the hypothalamus of the rat after exposure to cannabis vapors as compared to air. Alternative polyadenylation (APA) sites were identified using Whole Transcriptome Termini Sequencing (WTTS-seq). Data taken from Table 1. Values presented are p-values.
Authors:
Julianna N Brutman, Shuwen Zhang, Pique Choi, Yangzi Zhang, Meagan J Stotts, Jennifer Michal, Zhihua Jiang, Jon F Davis
243 down-regulated and 66 up-regulated genes in the hypothalamus of the rat after exposure to cannabis vapors as compared to air. Alternative polyadenylation (APA) sites were identified using Whole Transcriptome Termini Sequencing (WTTS-seq). Data taken from Supplementary Table S2. Values presented are p-adjusted values.
Authors:
Julianna N Brutman, Shuwen Zhang, Pique Choi, Yangzi Zhang, Meagan J Stotts, Jennifer Michal, Zhihua Jiang, Jon F Davis
9 target genes of interest in the nucleus accumbens of ~90 day old male Sprague-Dawley rats following heroin self-administration. Genes identified via RNA-seq were confirmed using qPCR. Data taken from Supplemental Table 1. Values presented are "1" for presence.
587 of the 685 genes differentially expressed in the nucleus accumbens of ~90 day old male Sprague-Dawley rats following heroin self-administration. Gene expression was identified via RNA-seq. Data taken from Supplemental Table 2. Values presented are fold change between the large suppressor of the heroin-paired taste cue and saline.
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