Studies using mice with beta4 nicotinic acetylcholine receptor (nAChR) subunit deficiency (beta4-/- mice) helped reveal the roles of this subunit in bradycardiac response to vagal stimulation, nicotine-induced seizure activity and anxiety. To identify genes that might be related to beta4-containing nAChRs activity, we compared the mRNA expression profiles of brains from beta4-/- and wild-type mice using Affymetrix U74Av2 microarray. Seventy-seven genes are significantly differentiated.
Neocortex Gene Expression Correlates for MDMA_ACT_SAL_1 measured in BXD RI Females & Males obtained using GeneNetwork Neocortex ILM6v1.1 (Feb08) RankInv. The MDMA_ACT_SAL_1 measures Locomotor activity of mice on Day 1 under the domain MDMA. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Ethanol induced LORR Chr# 2 rs13476399(28144658) with right flanking marker rs3713997(3151175) and left marker rs3679483 (179861211). This was mapped in 300 + (b6x129)F2 mice.
QTL associated with bone marrow graft rejection 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (40851001)
Authors:
Johansson MH, Taylor MA, Jagodic M, Tus K, Schatzle JD, Wakeland EK, Bennett M
QTL associated with cobblestone area-forming cell number QTL 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (40654653)
Authors:
van Os R, Ausema A, Noach EJ, van Pelt K, Dontje BJ, Vellenga E, de Haan G
QTL associated with variability in response to cholestrol enriched atherogenic diet. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (8665223)
QTL associated with femoral cross-sectional area 5. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (24644623)
Authors:
Klein RF, Turner RJ, Skinner LD, Vartanian KA, Serang M, Carlos AS, Shea M, Belknap JK, Orwoll ES
QTL associated with induction of brown adipocytes 6. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (20928232)
QTL associated with non-insulin-dependent diabetes mellitus 5. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (56934064)
QTL associated with periosteal circumference and femur length 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (25201804)
Authors:
Masinde GL, Wergedal J, Davidson H, Mohan S, Li R, Li X, Baylink DJ
QTL associated with platelet quantitative locus 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (31180075)
QTL associated with pentylenetetrazol induced seizure susceptibility 1b. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (25905794)
Authors:
Wakana S, Sugaya E, Naramoto F, Yokote N, Maruyama C, Jin W, Ohguchi H, Tsuda T, Sugaya A, Kajiwara K
QTL associated with spinal bone mineral density 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (31180075)
QTL associated with spinal bone mineral density 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (31180075)
Authors:
Zhang Q, Qiu P, Arreaza MG, Simon JS, Golovko A, Laverty M, Vassileva G, Gustafson EL, Rojas-Triana A, Bober LA, Hedrick JA, Monsma FJ Jr, Greene JR, Bayne ML, Murgolo NJ
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