Search Results :: GeneWeaver

Javascript must be enabled to properly use this website.

Search GeneSets

like "mouse, Ap3m2, alcohol"

GeneSets

Genes

Abstracts

Annotations

Tier

Species

Size

Attr.

GeneSet

Tier I

531

GS86746: Table S5: List of Cocaine-Treated WT vs. Saline-Treated WT Significantly Regulated Genes. [DRG]

Tier IV

51200

GS405734: WWP1 KO vs WT

Tier III

10946

GS407770: PPAR agonists regulate brain gene expression: Prefrontal cortex alcohol consumption mice fenofibrate q-value

Figure Label:	Prefrontal cortex alcohol consumption mice fenofibrate q-value
Description:	Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that act as ligand-activated transcription factors. Although prescribed for dyslipidemia and type-II diabetes, PPAR agonists also possess anti-addictive characteristics. PPAR agonists decrease ethanol consumption and reduce withdrawal severity and susceptibility to stress-induced relapse in rodents. However, the cellular and molecular mechanisms facilitating these properties have yet to be investigated. We tested three PPAR agonists in a continuous access two-bottle choice (2BC) drinking paradigm and found that tesaglitazar (PPARα/γ; 1.5 mg/kg) and fenofibrate (PPARα; 150 mg/kg) decreased ethanol consumption in male C57BL/6J mice while bezafibrate (PPARα/γ/β; 75 mg/kg) did not. We hypothesized that changes in brain gene expression following fenofibrate and tesaglitazar treatment lead to reduced ethanol drinking. We studied unbiased genomic profiles in areas of the brain known to be important for ethanol dependence, the prefrontal cortex (PFC) and amygdala, and also profiled gene expression in liver. Genomic profiles from the non-effective bezafibrate treatment were used to filter out genes not associated with ethanol consumption. Because PPAR agonists are anti-inflammatory, they would be expected to target microglia and astrocytes. Surprisingly, PPAR agonists produced a strong neuronal signature in mouse brain, and fenofibrate and tesaglitazar (but not bezafibrate) targeted a subset of GABAergic interneurons in the amygdala. Weighted gene co-expression network analysis (WGCNA) revealed co-expression of treatment-significant genes. Functional annotation of these gene networks suggested that PPAR agonists might act via neuropeptide and dopaminergic signaling pathways in the amygdala. Our results reveal gene targets through which PPAR agonists can affect alcohol consumption behavior.
Authors:	Laura B Ferguson, Dana Most, Yuri A Blednov, R Adron Harris

Manage GeneSets

Analyze GeneSets

Manage Accounts

GeneWeaver Links

Policies

Supported by NIH R01 AA18776 jointly funded by NIAAA and NIDA, and JAX Center for Precision Genetics NIH U54 OD 020351

Application Version 1.4.7