GeneSet Information

Tier I GS86746 • Table S5: List of Cocaine-Treated WT vs. Saline-Treated WT Significantly Regulated Genes. [DRG]

DESCRIPTION:

Chronic cocaine - Cocaine vs. Saline DNA microarray increased expression 20 mg / kg / day for 7 days Pair-wise comparisons were made between all 4 conditions (WT Saline, WT Cocaine, KO Saline, KO Cocaine), which generated 4 lists of genes 1.2-fold differentially expressed with a P < 0.05. Genes that were significantly regulated by these criteria in the first duplicate study and validated directly via qPCR were included in the final lists. (NIF Table ID 36 [42])

LABEL:

Mouse Chronic Cocaine vs. Saline

SCORE TYPE:

P-Value

DATE ADDED:

2010-11-03

DATE UPDATED:

2024-10-22

SPECIES:

URI:

http://neuinfo.org/

AUTHORS:

Renthal W, Maze I, Krishnan V, Covington HE 3rd, Xiao G, Kumar A, Russo SJ, Graham A, Tsankova N, Kippin TE, Kerstetter KA, Neve RL, Haggarty SJ, McKinsey TA, Bassel-Duby R, Olson EN, Nestler EJ

TITLE:

Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli.

JOURNAL:

Neuron Nov 2007, Vol 56, pp. 517-29

ABSTRACT:

Previous work has identified alterations in histone acetylation in animal models of drug addiction and depression. However, the mechanisms which integrate drugs and stress with changes in chromatin structure remain unclear. Here, we identify the activity-dependent class II histone deacetylase, HDAC5, as a central integrator of these stimuli with changes in chromatin structure and gene expression. Chronic, but not acute, exposure to cocaine or stress decreases HDAC5 function in the nucleus accumbens (NAc), a major brain reward region, which allows for increased histone acetylation and transcription of HDAC5 target genes. This regulation is behaviorally important, as loss of HDAC5 causes hypersensitive responses to chronic, not acute, cocaine or stress. These findings suggest that proper balance of histone acetylation is a crucial factor in the saliency of a given stimulus and that disruption of this balance is involved in the transition from an acute adaptive response to a chronic psychiatric illness. PUBMED: 17988634
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Annotation Information

No sequence read archive data associated with this GeneSet.


Social Control, Formal (D012926)
Brain (D001921)
Animals (D000818)
DNA (D004247)
Depression (D003863)
Mice (D051379)
Substance-Related Disorders (D019966)
Emotions (D004644)
Models, Animal (D023421)
Classification (D002965)
Dopamine Uptake Inhibitors (D018765)
Work (D014937)
Epigenesis, Genetic (D044127)
Adaptation, Physiological (D000222)
Pharmaceutical Preparations (D004364)
Cocaine-Related Disorders (D019970)
Acetylation (D000107)
Nucleus Accumbens (D009714)
Oligonucleotide Array Sequence Analysis (D020411)
Cocaine (D003042)
Mice, Inbred C57BL (D008810)
Disease Models, Animal (D004195)
Chronic Disease (D002908)
Stress, Psychological (D013315)
Reward (D012201)
Chromatin (D002843)
Gene Expression Regulation, Enzymologic (D015971)
Histone Deacetylases (D006655)
Histones (D006657)
Diagnosis-Related Groups (D003953)
brain (MA:0000168)
addiction (MP:0002555)
chromatin (GO:0000785)
nucleus (GO:0005634)
histone acetylation (GO:0016573)
gene expression (GO:0010467)
Trait (VT:0000001)
response to cocaine trait (VT:0010718)
response to addictive substance trait (VT:0010488)
response to xenobiotic stimulus trait (VT:0010487)
organism trait (VT:0010454)

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Supported by NIH R01 AA18776 jointly funded by NIAAA and NIDA, and JAX Center for Precision Genetics NIH U54 OD 020351

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