GeneSet Title
Tier V
Rat
683 Genes
GS248528
LABEL: Rat NAc Transcriptome & HeroinDESCRIPTION: Male Sprague-Dawley Rats were exposed to a saccharin solution for 5 minutes, then given the option to self-administer saccharin or heroin for 6 hours. This acted as a representation of the rat's "suppressing" ability. Following testing the rats were sacrificed and the nucleus accumbens was removed. Following RNA-seq an analysis was performed to identify significant and differentially expressed, transcripts with a read count of >1 on at least 100% of the samples in one group and with a fold change of > 1.25 were considered differentially expressed.
Tier V
Rat
666 Genes
GS357707
LABEL: RNA-seq experiment investigating the effects of heroin self administration in Sprague-Dawley ratsDESCRIPTION: Assessment of individual differences in the rat nucleus accumbens transcriptome following taste-heroin extended access
Tier IV
Rat
9 Genes
GS399925
LABEL: Rat NAc Heroin targetDESCRIPTION: 9 target genes of interest in the nucleus accumbens of ~90 day old male Sprague-Dawley rats following heroin self-administration. Genes identified via RNA-seq were confirmed using qPCR. Data taken from Supplemental Table 1. Values presented are "1" for presence.
Tier IV
Rat
1063 Genes
GS399926
LABEL: Rat heroin lg. suppressorDESCRIPTION: 587 of the 685 genes differentially expressed in the nucleus accumbens of ~90 day old male Sprague-Dawley rats following heroin self-administration. Gene expression was identified via RNA-seq. Data taken from Supplemental Table 2. Values presented are fold change between the large suppressor of the heroin-paired taste cue and saline.
Tier IV
Rat
366 Genes
GS399927
LABEL: Rat NAc Heroin 1hDESCRIPTION: 205 differentially expressed transcripts in the nucleus accumbens of ~90 day old male Sprague-Dawley rats following heroin self-administrations within 1 h. Gene expression was identified via RNA-seq. Data taken from Supplemental Table 3. Values presented are correlations.
Tier IV
Rat
162 Genes
GS399928
LABEL: Rat NAc Heroin 6hDESCRIPTION: 105 differentially expressed transcripts in the nucleus accumbens of ~90 day old male Sprague-Dawley rats following heroin self-administrations within 6 h. Gene expression was identified via RNA-seq. Data taken from Supplemental Table 3. Values presented are correlations.
Tier IV
Rat
102 Genes
GS399929
LABEL: Rat NAc Heroin extinctDESCRIPTION: 103 differentially expressed transcripts in the nucleus accumbens of ~90 day old male Sprague-Dawley rats following heroin self-administrations during a period of extinction (responding on active spout not reinforced). Gene expression was identified via RNA-seq. Data taken from Supplemental Table 3. Values presented are correlations.
Tier IV
Rat
86 Genes
GS399930
LABEL: Rat NAc Heroin PRDESCRIPTION: 88 differentially expressed transcripts in the nucleus accumbens of ~90 day old male Sprague-Dawley rats following heroin self-administrations within the progressive ratio test (progressively increased number of operant responses required for subsequent heroin injections). Gene expression was identified via RNA-seq. Data taken from Supplemental Table 3. Values presented are correlations.
Tier IV
Rat
60 Genes
GS399931
LABEL: Rat NAc Heroin reinstate.DESCRIPTION: 57 differentially expressed transcripts in the nucleus accumbens of ~90 day old male Sprague-Dawley rats following heroin self-administrations within the reinstatement period (following extinction, rats given IV heroin injection and subsequent behavior monitored to test for relapse-like patterns). Gene expression was identified via RNA-seq. Data taken from Supplemental Table 3. Values presented are correlations.
Tier V
Rat
683 Genes
GS403522
LABEL: Rat NAc Transcriptome & HeroinDESCRIPTION: Male Sprague-Dawley Rats were exposed to a saccharin solution for 5 minutes, then given the option to self-administer saccharin or heroin for 6 hours. This acted as a representation of the rat's "suppressing" ability. Following testing the rats were sacrificed and the nucleus accumbens was removed. Following RNA-seq an analysis was performed to identify significant and differentially expressed, transcripts with a read count of >1 on at least 100% of the samples in one group and with a fold change of > 1.25 were considered differentially expressed.
Tier V
Rat
683 Genes
GS403523
LABEL: Rat NAc Transcriptome & HeroinDESCRIPTION: Male Sprague-Dawley Rats were exposed to a saccharin solution for 5 minutes, then given the option to self-administer saccharin or heroin for 6 hours. This acted as a representation of the rat's "suppressing" ability. Following testing the rats were sacrificed and the nucleus accumbens was removed. Following RNA-seq an analysis was performed to identify significant and differentially expressed, transcripts with a read count of >1 on at least 100% of the samples in one group and with a fold change of > 1.25 were considered differentially expressed.
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