GeneSet Information

Tier III GS926 • Brain Differential Expression after 1.90 mg/kg of Organo-chlorine s in Females

DESCRIPTION:

Differentially expressed genes in female cerebellum from microarray analysis. OC stands for Organochlorine Pesticides. Differential expression of OCs were compared against differential expression of MeHg, NCM, PCBs and PTU.

LABEL:

BrainDiffExp OCs Females

SCORE TYPE:

Binary

DATE ADDED:

2008-01-31

DATE UPDATED:

2020-05-06

SPECIES:

AUTHORS:

Padhi BK, Pelletier G, Williams A, Berndt-Weis L, Yauk C, Bowers WJ, Chu I

TITLE:

Gene expression profiling in rat cerebellum following in utero and lactational exposure to mixtures of methylmercury, polychlorinated biphenyls and organochlorine pesticides.

JOURNAL:

Toxicology letters Jan 2008, Vol 176, pp. 93-103

ABSTRACT:

Although human populations are continuously exposed to complex mixtures of contaminants, the effects of such exposure on the developing brain transcriptome are poorly characterized. Rats were exposed perinatally to the northern contaminant mixture (NCM) which was designed to reflect the blood contaminant profile of Canadian arctic populations, to components of the NCM administered separately (methylmercury (MeHg), polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCs)) or to the goitrogen propylthiouracyl. Post-natal day (PND) 14 cerebellum global gene expression resulting from such exposures was investigated using high-density cDNA microarrays. Fifty known genes were identified as differentially expressed between the control group and at least one other treatment group. The microarray data were validated by quantitative PCR (qPCR) on a subset of 10 genes. The differentially expressed genes are involved in a variety of processes, including nerve cell differentiation, migration, myelination and synaptic transmission. The comparison of cerebellum gene expression profiles resulting from exposure to the NCM and its individual components in male and female pups revealed that (i) gender is a crucial biological variable influencing genomic response to environmental contaminants and (ii) contaminant co-exposure significantly masks the effects of individual mixture components on cerebellum gene expression. PUBMED: 18077114
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Annotation Information

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Ribosomal Proteins (D012269)
Environmental Pollutants (D004785)
Brain (D001921)
Gender Identity (D005783)
Masks (D008397)
Animals (D000818)
Humans (D006801)
Sex Factors (D012737)
Polymerase Chain Reaction (D016133)
Complex Mixtures (D045424)
Gene Expression Profiling (D020869)
Methylmercury Compounds (D008767)
Emigration and Immigration (D004641)
Microarray Analysis (D046228)
Animals, Newborn (D000831)
Therapeutics (D013812)
Neurons (D009474)
Neuropeptides (D009479)
Extracellular Matrix Proteins (D016326)
Reverse Transcriptase Polymerase Chain Reaction (D020133)
Rats (D051381)
Oligonucleotide Array Sequence Analysis (D020411)
Hydrocarbons, Chlorinated (D006843)
Cells (D002477)
Pesticides (D010575)
Maternal Exposure (D018811)
Blood (D001769)
Cerebellum (D002531)
DNA, Complementary (D018076)
Control Groups (D035061)
Lactation (D007774)
Polychlorinated Biphenyls (D011078)
Calcium-Binding Proteins (D002135)
Cell Differentiation (D002454)
Pregnancy (D011247)
Guanine Nucleotide Exchange Factors (D020662)
Synaptic Transmission (D009435)
Rats, Sprague-Dawley (D017207)
Cluster Analysis (D016000)
blood (MA:0000059)
nerve (MA:0000217)
brain (MA:0000168)
cerebellum (MA:0000198)
synaptic transmission (GO:0007268)
cell (GO:0005623)
cell differentiation (GO:0030154)
gene expression (GO:0010467)
myelination (GO:0042552)

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Supported by NIH R01 AA18776 jointly funded by NIAAA and NIDA, and JAX Center for Precision Genetics NIH U54 OD 020351