GeneSet Information

Tier I GS87661 • Genetic Markers for Opiate and cocaine addiction

DESCRIPTION:

Genes mentioned in a review. See review for original publication refs.

LABEL:

addiction

SCORE TYPE:

Binary

DATE ADDED:

2010-12-15

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Yuferov V, Levran O, Proudnikov D, Nielsen DA, Kreek MJ

TITLE:

Search for genetic markers and functional variants involved in the development of opiate and cocaine addiction and treatment.

JOURNAL:

Annals of the New York Academy of Sciences Feb 2010, Vol 1187, pp. 184-207

ABSTRACT:

Addiction to opiates and illicit use of psychostimulants is a chronic, relapsing brain disease that, if left untreated, can cause major medical, social, and economic problems. This article reviews recent progress in studies of association of gene variants with vulnerability to develop opiate and cocaine addictions, focusing primarily on genes of the opioid and monoaminergic systems. In addition, we provide the first evidence of a cis-acting polymorphism and a functional haplotype in the PDYN gene, of significantly higher DNA methylation rate of the OPRM1 gene in the lymphocytes of heroin addicts, and significant differences in genotype frequencies of three single-nucleotide polymorphisms of the P-glycoprotein gene (ABCB1) between \"higher\" and \"lower\" methadone doses in methadone-maintained patients. In genomewide and multigene association studies, we found association of several new genes and new variants of known genes with heroin addiction. Finally, we describe the development and application of a novel technique: molecular haplotyping for studies in genetics of drug addiction. PUBMED: 20201854
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Annotation Information

No sequence read archive data associated with this GeneSet.


Brain (D001921)
Lymphocytes (D008214)
Genetic Variation (D014644)
Review (D016454)
Humans (D006801)
DNA (D004247)
Genetics (D005823)
Substance-Related Disorders (D019966)
Patients (D010361)
Heroin Dependence (D006556)
Methadone (D008691)
Opioid-Related Disorders (D009293)
Receptor, Serotonin, 5-HT1B (D044302)
Genome-Wide Association Study (D055106)
Tryptophan Hydroxylase (D014365)
Therapeutics (D013812)
Epigenesis, Genetic (D044127)
Enkephalins (D004745)
Genotype (D005838)
Polymorphism, Genetic (D011110)
Receptors, Opioid, mu (D017450)
Cocaine-Related Disorders (D019970)
Cocaine (D003042)
Brain Diseases (D001927)
P-Glycoprotein (D020168)
Haplotypes (D006239)
Protein Precursors (D011498)
Catechol O-Methyltransferase (D002394)
Heroin (D003932)
Receptor, Melanocortin, Type 2 (D044103)
Receptors, Opioid, kappa (D017473)
DNA Methylation (D019175)
Pharmacogenetics (D010597)
Association (D001244)
Methylation (D008745)
brain (MA:0000168)
addiction (MP:0002555)
DNA methylation (GO:0006306)
methylation (GO:0032259)

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Supported by NIH R01 AA18776 jointly funded by NIAAA and NIDA, and JAX Center for Precision Genetics NIH U54 OD 020351