GeneSet Information

Tier I GS87571 • Table S4: Effect of G9a overexpression on genes that display increased mRNA induction in NAc following repeated cocaine. (Whole Table) [DRG]

DESCRIPTION:

Chronic cocaine - Cocaine vs. Saline Viral vectors followed by DNA microarray Change in gene expression Mice received intra-Nucleus accumbens injections of herpes simplex virus (HSV) vectors expressing green fluorescent protein (GFP). Following HSV-GFP infection, mice were treated with saline (5 treatments saline, intraperitoneal) or repeated cocaine (5 treatments 20 mg / kg cocaine-HCl, intraperitoneal) over the course of 3 days. Significance was determined using student?s t tests. P < 0.05. (NIF Method ID 228)

LABEL:

Chronic cocaine - Cocaine vs. Saline

SCORE TYPE:

P-Value

DATE ADDED:

2010-11-03

DATE UPDATED:

2024-04-25

SPECIES:

URI:

http://neuinfo.org/

AUTHORS:

Maze I, Covington HE 3rd, Dietz DM, LaPlant Q, Renthal W, Russo SJ, Mechanic M, Mouzon E, Neve RL, Haggarty SJ, Ren Y, Sampath SC, Hurd YL, Greengard P, Tarakhovsky A, Schaefer A, Nestler EJ

TITLE:

Essential role of the histone methyltransferase G9a in cocaine-induced plasticity.

JOURNAL:

Science (New York, N.Y.) Jan 2010, Vol 327, pp. 213-6

ABSTRACT:

Cocaine-induced alterations in gene expression cause changes in neuronal morphology and behavior that may underlie cocaine addiction. In mice, we identified an essential role for histone 3 lysine 9 (H3K9) dimethylation and the lysine dimethyltransferase G9a in cocaine-induced structural and behavioral plasticity. Repeated cocaine administration reduced global levels of H3K9 dimethylation in the nucleus accumbens. This reduction in histone methylation was mediated through the repression of G9a in this brain region, which was regulated by the cocaine-induced transcription factor DeltaFosB. Using conditional mutagenesis and viral-mediated gene transfer, we found that G9a down-regulation increased the dendritic spine plasticity of nucleus accumbens neurons and enhanced the preference for cocaine, thereby establishing a crucial role for histone methylation in the long-term actions of cocaine. PUBMED: 20056891
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Annotation Information

No sequence read archive data associated with this GeneSet.


Brain (D001921)
Gene Expression Regulation (D005786)
Students (D013334)
Proto-Oncogene Proteins c-fos (D016760)
Self Administration (D012646)
Animals (D000818)
DNA (D004247)
Behavior (D001519)
Mice (D051379)
Spine (D013131)
Gene Expression Profiling (D020869)
Behavior, Animal (D001522)
Herpes Simplex (D006561)
Transfer (Psychology) (D014163)
RNA, Messenger (D012333)
Enzyme Repression (D004794)
Therapeutics (D013812)
Role (D012380)
Neurons (D009474)
Neuronal Plasticity (D009473)
Dendritic Spines (D049229)
Down-Regulation (D015536)
Cocaine-Related Disorders (D019970)
Nucleus Accumbens (D009714)
Oligonucleotide Array Sequence Analysis (D020411)
Cocaine (D003042)
Viruses (D014780)
Mice, Inbred C57BL (D008810)
Repression, Psychology (D012094)
Transcription, Genetic (D014158)
Transcription Factors (D014157)
Histone-Lysine N-Methyltransferase (D011495)
Organization and Administration (D009934)
Simplexvirus (D018139)
Infection (D007239)
Lysine (D008239)
Reward (D012201)
Mutagenesis (D016296)
Histones (D006657)
Injections (D007267)
Diagnosis-Related Groups (D003953)
Methylation (D008745)
brain (MA:0000168)
addiction (MP:0002555)
nascent polypeptide-associated complex (GO:0005854)
methylation (GO:0032259)
nucleus (GO:0005634)
dendritic spine (GO:0043197)
gene expression (GO:0010467)
behavior (GO:0007610)
histone methylation (GO:0016571)

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Supported by NIH R01 AA18776 jointly funded by NIAAA and NIDA, and JAX Center for Precision Genetics NIH U54 OD 020351