DESCRIPTION:
Chronic ethanol - Ethanol vs. Control DNA microarray Change in gene expression - Class I Alcoholics were classified based on the quantity of alcohol consumed, according to the National Health and Medical Research Council (NHMRC) (>80 g of alcohol per day), instead of the criteria established by the American Psychiatric Association (DSM-IV) or the World Health Organization (ICD-10). Many alcoholic patients in this study consumed significantly more than 80 g / day for most of their adult life. Cerebral atrophy was observed in three alcoholic cases. All alcoholic cases included in our Axon GenePix 4.0 software; partial least squares (PLS) statistical procedure; linear discriminant analysis (LDA) procedure for prediction analysis. PLS and LDA analysis were performed using in JMP IN software; principal component analysis (PCA) used STATISTICA software. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. They represent those that were more likely turned off or turned on as a result of alcohol abuse. Genes were selected that were consistently expressed in the controls but not the alcoholics, or were consistently expressed in the alcoholics but not the controls. Consistently detected genes in a given group were defined as those detected on over 50% of the arrays of that group. Genes were then selected that were consistently detected in one group but not the other. In addition, only those genes that were detected over twice as frequently in one group compared to the other were considered Class I. Thus, Class I genes were those detected on at least eight more arrays in one group than the other. (NIF Table ID 248 [155])
LABEL:
Chronic ethanol - Ethanol vs. Control
SCORE TYPE:
Binary
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Uploaded As | Gene Symbol | Homology | Score | Priority | LinkOuts | Emphasis |
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