GeneSet Information

Tier II GS84177 • morphine preference (Published QTL, Chr 6)

DESCRIPTION:

morphine preference spans 0.00 - 26.89 Mbp (NCBI Build 37) on Chr6. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).

LABEL:

QTL for morphine preference on Chr6 at NA (1.89 Mbp , Build 37)

SCORE TYPE:

Binary

DATE ADDED:

2010-10-01

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Primo-Parmo SL, Sorenson RC, Teiber J, La Du BN

TITLE:

The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family.

JOURNAL:

Genomics May 1996, Vol 33, pp. 498-507

ABSTRACT:

A physiological role for paraoxonase (PON1) is still uncertain, but it catalyzes the hydrolysis of toxic organophosphates. Evidence that the human genome contains two PON1-like genes, designated PON2 and PON3, is presented here. Human PON1 and PON2 each have nine exons, and the exon/intron junctions occur at equivalent positions. PON1 and PON2 genes are both on chromosome 7 in human and on chromosome 6 in the mouse. Turkey and chicken, like most birds, lack paraoxonase activity and are very susceptible to organophosphates. However, they have a PON-like gene with approximately 70% identity with human PON1, PON2, and PON3. Another unexpected finding is that the deduced amino acid sequences of PON2 in human, mouse, dog, turkey, and chicken and of human PON3 are all missing the amino acid residue 105, which is lysine in human PON1. The expanded number of PON genes will have important implications for future experiments designed to discover the individual functions, catalytic properties, and physiological roles of the paraoxonases. PUBMED: 8661009
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Annotation Information

No sequence read archive data associated with this GeneSet.


Chromosomes, Human, Pair 6 (D002896)
Chromosomes, Human, Pair 7 (D002897)
Exons (D005091)
Family (D005190)
Forecasting (D005544)
Humans (D006801)
Genome, Human (D015894)
Serum (D044967)
Mice (D051379)
Chromosomes (D002875)
Hydrolysis (D006868)
Role (D012380)
Aryldialkylphosphatase (D043303)
Birds (D001717)
Dogs (D004285)
Informatics (D048088)
Chickens (D002645)
Multigene Family (D005810)
Lysine (D008239)
Amino Acid Sequence (D000595)
Turkey (D014421)
Morphine (D009020)
Introns (D007438)
Phosphoric Acid Esters (D010755)
serum (MA:0002502)
chromosome (GO:0005694)

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Supported by NIH R01 AA18776 jointly funded by NIAAA and NIDA, and JAX Center for Precision Genetics NIH U54 OD 020351