DESCRIPTION:

ethanol induced locomotion spans 175.10 - 225.10 Mbp (NCBI Build 37) on Chr1. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).

LABEL:

QTL for ethanol induced locomotion on Chr1 at NA (200.10 Mbp , Build 37)

SCORE TYPE:

Binary

DATE ADDED:

2010-10-01

DATE UPDATED:

2020-05-06

SPECIES:

AUTHORS:

Hitzemann R, Demarest K, Koyner J, Cipp L, Patel N, Rasmussen E, McCaughran J Jr

TITLE:

Effect of genetic cross on the detection of quantitative trait loci and a novel approach to mapping QTLs.

JOURNAL:

Pharmacology, biochemistry, and behavior Dec 2000, Vol 67, pp. 767-72

ABSTRACT:

A genome-wide scan was conducted in two F(2) intercrosses, C57BL/6J (B6)xDBA/2J (D2) and BALB/cJ (C)xLP/J (LP), for three different phenotypes: basal locomotor activity, ethanol-induced locomotor activity, and haloperidol-induced catalepsy. For basal activity, significant quantitative trait loci (QTLs, LOD> or =4.3) were detected on chromosomes 9 and 19 for the CxLP intercross and chromosome 1 for the B6xD2 intercross. Significant QTLs for ethanol-induced activation were detected on chromosome 6 for the CxLP intercross, and on chromosomes 1 and 2 for the B6xD2 intercross. For haloperidol-induced catalepsy, significant QTLs were detected on chromosome 14 (two different QTLs) in the CxLP intercross, and chromosomes 1 and 9 in the B6xD2 intercross. These data illustrate the importance of the genetic cross for QTL detection. Finally, the data reported here, and elsewhere, are also used to demonstrate a novel approach to QTL detection and localization. PUBMED: 11166067
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