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GS84101 • ethanol withdrawal on Chr1 at D1Mit122 (Published QTL, Chr 1)
ethanol withdrawal spans 17.42 - 67.42 Mbp (NCBI Build 37) on Chr1. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL for ethanol withdrawal on Chr1 at D1Mit122 (42.42 Mbp , Build 37)
Provisional mapping of quantitative trait loci for chronic ethanol withdrawal severity in BXD recombinant inbred mice.
The Journal of pharmacology and experimental therapeutics
Vol 286, pp. 263-71
Male mice from C57BL/6J (B6), DBA/2J (D2) and their 25 recombinant inbred (RI) strains were exposed to ethanol (EtOH) vapor (3.0-9.0 mg EtOH/liter of air) for 72 hr. Mice were selected such that each strain averaged 1.34 to 1.59 mg of EtOH/ml of blood on withdrawal. Control groups and EtOH-exposed groups were tested hourly for handling-induced convulsions (HIC) for 10 hr and at hr 24 and 25. Strain withdrawal severity was indexed as the area under the 25-hr HIC curve for the EtOH group minus that strain\'s equivalent value for the control group. Genome-wide quantitative trait locus (QTL) analyses correlating strain means with allelic status at > 1500 markers identified 10 chromosomal regions at P < .01. These provisionally identified QTLs were on chromosomes 1 (2 QTLs), 3, 9 (2 QTLs), 10, 12, 13, 15 and 18. Multiple regression analysis using the four most influential QTLs revealed that these loci controlled 86% of the genetic variance. A QTL mapped to distal chromosome 1 (P < .001) is in the same region as one previously definitively mapped for acute alcohol withdrawal, as well as one mapped for acute pentobarbital withdrawal. Several of the QTLs map near potential candidate genes. These provisional linkages will now be confirmed or rejected using additional genetically segregating populations.
PUBMED: 9655868 Find other GeneSets from this publication