DESCRIPTION:

alcohol preference locus spans 0.00 - 47.09 Mbp (NCBI Build 37) on Chr1. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).

LABEL:

QTL for alcohol preference locus on Chr1 at D1Mit295 (22.09 Mbp , Build 37)

SCORE TYPE:

Binary

DATE ADDED:

2010-10-01

DATE UPDATED:

2024-10-22

SPECIES:

AUTHORS:

Peirce JL, Derr R, Shendure J, Kolata T, Silver LM

TITLE:

A major influence of sex-specific loci on alcohol preference in C57Bl/6 and DBA/2 inbred mice.

JOURNAL:

Mammalian genome : official journal of the International Mammalian Genome Society Dec 1998, Vol 9, pp. 942-8

ABSTRACT:

C57Bl/6 mice reproducibly prefer to ingest more 10% ethanol in a two-bottle choice paradigm than do DBA/2J mice. In this paper we report the identification of two new sex-specific alcohol preference (Alcp) loci. Melo and associates (1996) identified two loci: Alcp1, a male-specific locus on Chromosome (Chr) 2, and Alcp2, a female- and cross-specific locus on Chr 11. We have additionally identified Alcp3, a male-specific locus on Chr 3, and Alcp4, a female-specific locus on Chr 1. We have also performed a statistical analysis to exclude the possibility of undiscovered major alcohol preference loci that are not sex-specific in our backcross paradigm. Our results indicate that alcohol preference in C57BL/6 mice, as measured in our backcross, is largely controlled in a sex-specific manner. PUBMED: 9880657
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