GeneSet Information

Tier II GS83965 • cocaine induced activation 10 (Cocia10, Published QTL, Chr 9, MGI:3040201)

DESCRIPTION:

cocaine induced activation 10 (Cocia10) spans 16.695932 - 66.695932 Mbp (NCBI Build 37) on Chr 9. Obtained from MGI (http://www.informatics.jax.org) by searching for QTLs containing the keyword .

LABEL:

QTL-Cocia10-Chr9

SCORE TYPE:

Binary

DATE ADDED:

2010-08-16

DATE UPDATED:

2019-01-07

SPECIES:

AUTHORS:

Gill KJ, Boyle AE

TITLE:

Confirmation of quantitative trait loci for cocaine-induced activation in the AcB/BcA series of recombinant congenic strains.

JOURNAL:

Pharmacogenetics Jun 2003, Vol 13, pp. 329-38

ABSTRACT:

Individual differences in the psychomotor stimulant effects of cocaine are influenced by genetic factors. Several quantitative trait loci (QTL) have been identified for cocaine-induced locomotor activation using the AXB/BXA recombinant inbred series of strains derived from the A/J (A) and C57BL/6J (B6). The aim of the present study was to conduct an independent analysis of cocaine-induced activation in the AcB/BcA recombinant congenic strains. The AcB/BcA RC series consists of 37 inbred strains derived from reciprocal backcrosses between the A and B6, followed by systematic inbreeding. Locomotor activity was measured in a computerized open-field apparatus following intraperitoneal administration of saline and cocaine (20 mg/kg). Linkage maps constructed with 625 informative microsatellite markers were used to identify chromosomal regions associated with cocaine difference scores. Significant (P < 0.00001) regions were identified on chromosomes 1 (13-25.7 and 36.9-58.5 cM), 5 (1-28 and 84-86 cM), 6 (7-26.35 cM), 7 (9.4-27.8 cM), 9 (9-28 cM), 13 (21-37 cM), 16 (36-66 cM), 17 (22.5-24.5 cM) and 18 (45-48 cM). Multiple regression analysis demonstrated that a subset of four markers, including D5Mit182 (24 cM), D5Mit409 (84 cM), D7Mit83 (26.5 cM) and D13Mit54 (35 cM), accounted for 90% of the genetic variance in cocaine difference scores. The results of the present study provide confirmation for a number of QTL on chromosomes 1, 5, 6, 9, 16 and 17 which were previously identified in the recombinant inbred AXB/BXA and BXD strains that share a common B6 ancestor. PUBMED: 12777963
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Annotation Information



Motor Activity (D009043)
Individuality (D007206)
Chromosomes (D002875)
Quantitative Trait Loci (D040641)
Microsatellite Repeats (D018895)
Inbreeding (D007178)
Cocaine (D003042)
Informatics (D048088)
Organization and Administration (D009934)
Regression Analysis (D012044)
Regression (Psychology) (D012043)

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