GeneSet Information

Tier III GS75764 • Selected genes induced in Th17 cells

DESCRIPTION:

Total cellular RNA from Th0 and Th17 cells were subjected to microarray analysis. Fold induction was represented by the ratio of normalized gene expression in Th17 cells versus the expression in Th0 cells.

LABEL:

Genes Induc. Th17 Cells

SCORE TYPE:

DATE ADDED:

2010-07-06

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Wei L, Laurence A, Elias KM, O\'Shea JJ

TITLE:

IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner.

JOURNAL:

The Journal of biological chemistry Nov 2007, Vol 282, pp. 34605-10

ABSTRACT:

CD4(+) helper T cells can differentiate into several possible fates including: Th1, Th2, T regulatory, and Th17 cells. Although, cytokine production by non-T cells is an important factor in helper T cell differentiation, a characteristic feature of both Th1 and Th2 lineages is their ability to secrete cytokines that promote their respective differentiation. However, cytokines produced by T cells that help to sustain Th17 cells have not yet been identified. Here we show that IL-21 is a product of Th17 cells, which is induced in a Stat3-dependent manner. Additionally, Stat3 can directly bind the Il21 promoter. IL-21 also induces IL-17 production and expression of the transcription factor, RORgammat. Furthermore, generation of Th17 cells in the conventional manner is attenuated by blocking IL-21. IL-21 is known to activate Stat3 and its ability to induce Th17 differentiation is abrogated in the absence of Stat3. These data argue that IL-21 serves as an autocrine factor secreted by Th17 cells that promotes or sustains Th17 lineage commitment. PUBMED: 17884812
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Annotation Information

No sequence read archive data associated with this GeneSet.


T-Lymphocytes (D013601)
Gene Expression Regulation (D005786)
Aptitude (D001076)
Animals (D000818)
RNA (D012313)
Promoter Regions, Genetic (D011401)
STAT3 Transcription Factor (D050796)
Cytokines (D016207)
Nuclear Receptor Subfamily 1, Group F, Member 3 (D057132)
Mice (D051379)
Cell Lineage (D019070)
CD4-Positive T-Lymphocytes (D015496)
Microarray Analysis (D046228)
Spleen (D013154)
Drive (D004328)
Th17 Cells (D058504)
Receptors, Retinoic Acid (D018168)
Oligonucleotide Array Sequence Analysis (D020411)
Mice, Inbred C57BL (D008810)
Interleukins (D007378)
Cells (D002477)
Transcription Factors (D014157)
T-Lymphocytes, Helper-Inducer (D006377)
Interleukin-17 (D020381)
Cell Differentiation (D002454)
Receptors, Thyroid Hormone (D011988)
cell (GO:0005623)
cell differentiation (GO:0030154)
T cell differentiation (GO:0030217)
T-helper cell differentiation (GO:0042093)
interleukin-17 production (GO:0032620)
cytokine production (GO:0001816)
gene expression (GO:0010467)

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Supported by NIH R01 AA18776 jointly funded by NIAAA and NIDA, and JAX Center for Precision Genetics NIH U54 OD 020351