GeneSet Information

Tier III GS75754 • Prefrontal cortex gene expression in postmortem human alcoholics

DESCRIPTION:

Oligonucleotide microarray analysis in postmortem prefrontal cortices of alcoholics. Among about 12,000 genes represented on microarray, a total of 79 genes showed differential expression changes in alcoholics compared with control subjects, consisting of 54 up- and 25 down-regulated genes. From Iwamoto et al., 2004.

LABEL:

prefront cort human alco

SCORE TYPE:

Effect

DATE ADDED:

2010-07-01

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Iwamoto K, Bundo M, Yamamoto M, Ozawa H, Saito T, Kato T

TITLE:

Decreased expression of NEFH and PCP4/PEP19 in the prefrontal cortex of alcoholics.

JOURNAL:

Neuroscience research Aug 2004, Vol 49, pp. 379-85

ABSTRACT:

Patients with alcoholism exhibit behavioral adaptations to ethanol such as tolerance, dependence, and addiction. Molecular mechanisms that underlie these altered behavioral responses to ethanol are largely unclear. We have performed oligonucleotide microarray analysis in postmortem prefrontal cortices of alcoholics. Among about 12,000 genes represented on microarray, a total of 79 genes showed differential expression changes in alcoholics compared with control subjects, consisting of 54 up- and 25 down-regulated genes. Altered expressions in alcoholics were observed in genes having a wide range of biological functions. The remarkable findings were up-regulation of myelin-related genes and molecular chaperones in alcoholics. Among the genes identified, decreased expressions of NEFH and PCP4/PEP19 were further examined. NEFH encodes a component of neurofilament protein in neurons. PCP4/PEP19 encodes protein involved in calcium signaling and neuronal apoptosis. Observation of their down-regulations in alcoholics in microarray analysis was confirmed by real-time quantitative RT-PCR, and was also confirmed in the independent set of postmortem brains of alcoholics. The present results may provide some insights into understanding the mechanism of ethanol-induced altered behavioral responses at the molecular level. PUBMED: 15236863
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Brain (D001921)
Molecular Chaperones (D018832)
Humans (D006801)
Sex Factors (D012737)
Calcium (D002118)
Patients (D010361)
Comprehension (D032882)
Calcium Signaling (D020013)
Adult (D000328)
Microarray Analysis (D046228)
RNA, Messenger (D012333)
Central Nervous System Depressants (D002492)
Middle Aged (D008875)
Neurons (D009474)
Reverse Transcriptase Polymerase Chain Reaction (D020133)
Prefrontal Cortex (D017397)
Up-Regulation (D015854)
Oligonucleotide Array Sequence Analysis (D020411)
Nerve Tissue Proteins (D009419)
Alcoholics (D057229)
Observation (D019370)
Aged (D000368)
Aged, 80 and over (D000369)
Age Factors (D000367)
Set (Psychology) (D012718)
Alcoholism (D000437)
Ethanol (D000431)
Neurofilament Proteins (D016900)
Apoptosis (D017209)
addiction (MP:0002555)
calcium-mediated signaling (GO:0019722)
neurofilament (GO:0005883)
gene expression (GO:0010467)
signaling (GO:0023052)

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Supported by NIH R01 AA18776 jointly funded by NIAAA and NIDA, and JAX Center for Precision Genetics NIH U54 OD 020351