GeneSet Information

Tier III GS75716 • Power to detect effect sizes reported previously with T1D in current cohort of 3,962 RA cases and 3,531 controls - Celiac Disease

DESCRIPTION:

The concept of susceptibility genes common to different autoimmune diseases is now firmly established with previous studies demonstrating overlap of loci conferring susceptibility to type 1 diabetes (T1D) with both Coeliac disease and multiple sclerosis. Rheumatoid arthritis (RA) is an archetypal autoimmune disease and we, therefore, targeted putative T1D susceptibility loci for genotyping in UK RA cases and unrelated controls.

LABEL:

CelDis. and AutoImmune

SCORE TYPE:

Effect

DATE ADDED:

2010-06-30

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Barton A, Eyre S, Ke X, Hinks A, Bowes J, Flynn E, Martin P, Wilson AG, Morgan AW, Emery P, Steer S, Hocking LJ, Reid DM, Harrison P, Wordsworth P, Thomson W, Worthington J

TITLE:

Identification of AF4/FMR2 family, member 3 (AFF3) as a novel rheumatoid arthritis susceptibility locus and confirmation of two further pan-autoimmune susceptibility genes.

JOURNAL:

Human molecular genetics Jul 2009, Vol 18, pp. 2518-22

ABSTRACT:

The concept of susceptibility genes common to different autoimmune diseases is now firmly established with previous studies demonstrating overlap of loci conferring susceptibility to type 1 diabetes (T1D) with both Coeliac disease and multiple sclerosis. Rheumatoid arthritis (RA) is an archetypal autoimmune disease and we, therefore, targeted putative T1D susceptibility loci for genotyping in UK RA cases and unrelated controls. A novel RA susceptibility locus at AFF3 was identified with convincing evidence for association in a combined sample cohort of 6819 RA cases and 12 650 controls [OR 1.12 95% confidence intervals (CI) 1.07-1.17, P = 2.8 x 10(-7)]. Association of two previously described loci (CTLA-4 and 4q27) with RA was also replicated (OR 0.87, 95% CI 0.82-0.94, P = 1.1 x 10(-4) and OR 0.86, 95% CI 0.79-0.94, P = 5.4 x 10(-4), respectively). These findings take the number of established RA susceptibility loci to 13, only one of which has not been associated with other autoimmune diseases. PUBMED: 19359276
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Annotation Information

No sequence read archive data associated with this GeneSet.


Family (D005190)
Diabetes Mellitus, Type 1 (D003922)
Humans (D006801)
Nuclear Proteins (D009687)
Case-Control Studies (D016022)
Celiac Disease (D002446)
Adult (D000328)
Genome-Wide Association Study (D055106)
Genetic Predisposition to Disease (D020022)
Autoimmune Diseases (D001327)
Middle Aged (D008875)
Power (Psychology) (D011209)
Multiple Sclerosis (D009103)
Arthritis, Rheumatoid (D001172)
Sclerosis (D012598)
European Continental Ancestry Group (D044465)
Cohort Studies (D015331)
Multigene Family (D005810)
Identification (Psychology) (D007062)
Aged (D000368)
Arthritis (D001168)
Polymorphism, Single Nucleotide (D020641)
Association (D001244)
Confidence Intervals (D016001)
rheumatoid arthritis (MP:0003561)
arthritis (MP:0002993)

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Supported by NIH R01 AA18776 jointly funded by NIAAA and NIDA, and JAX Center for Precision Genetics NIH U54 OD 020351