GeneSet Information

Tier III GS75686 • Genes upregulated in inflamed mucosa compared with non-inflamed mucosa - Ulcerative Colitis

DESCRIPTION:

The genes which were significantly upregulated in inflamed mucosa compared with those of non-inflamed mucosa are listed. Migration inhibitory factor-related protein 14 (MRP14) and growth-related oncogene-gamma (GROc) were significant in all four statistical analyses of both of the individual and pairwise studies.

LABEL:

UpReg. infl.mucosa UC

SCORE TYPE:

Effect

DATE ADDED:

2010-06-24

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Okahara S, Arimura Y, Yabana T, Kobayashi K, Gotoh A, Motoya S, Imamura A, Endo T, Imai K

TITLE:

Inflammatory gene signature in ulcerative colitis with cDNA macroarray analysis.

JOURNAL:

Alimentary pharmacology & therapeutics May 2005, Vol 21, pp. 1091-7

ABSTRACT:

BACKGROUND: Most array analyses of ulcerative colitis have focused on identifying susceptibility genes for ulcerative colitis. AIM: To clarify the changes in gene expression during inflammation in ulcerative colitis colon mucosa using cDNA macroarray. METHODS: From 23 ulcerative colitis patients, 16 each of inflamed and non-inflamed specimens (total 32 samples for individual analysis) were obtained by colonoscopic biopsy. Eighteen of the 32 samples, used for pairwise analysis, consisted of nine sample pairs, each pair being from the same patient. We examined expression profiles of approximately 1300 genes with cDNA macroarray. Comparisons were made using two kinds of statistics, t-test and significance analysis of microarray in both analyses. The reproducibility of significant genes from the macroarray analysis was confirmed by real-time ploymerase chain reaction. RESULTS: We detected five upregulated genes, categorized into proinflammatory genes (MRP14, GRO gamma and SAA1) and anti-inflammatory genes (TIMP1 and Elafin) in inflamed mucosa, and one upregulated gene (L-FABP) in non-inflamed mucosa. CONCLUSIONS: As the cDNA macroarray analysis in this study exactly reflects the total profile of gene expression in the clinical setting of ulcerative colitis, the genes identified will be directly applicable to diagnostics or as novel therapeutic targets in active ulcerative colitis. PUBMED: 15854170
Find other GeneSets from this publication

Annotation Information

No sequence read archive data associated with this GeneSet.


Colon (D003106)
Fatty Acid-Binding Proteins (D050556)
Seminal Plasma Proteins (D029589)
RNA (D012313)
Humans (D006801)
Acrosome (D000177)
Proteinase Inhibitory Proteins, Secretory (D053491)
Patients (D010361)
Emigration and Immigration (D004641)
Antigens (D000941)
Carrier Proteins (D002352)
Statistics (D020500)
Adult (D000328)
Isoantigens (D007519)
Proteins (D011506)
Therapeutics (D013812)
Reverse Transcriptase Polymerase Chain Reaction (D020133)
Intercellular Signaling Peptides and Proteins (D036341)
Calgranulin B (D040502)
Up-Regulation (D015854)
Oligonucleotide Array Sequence Analysis (D020411)
Inflammation (D007249)
Tissue Inhibitor of Metalloproteinase-1 (D019715)
Methods (D008722)
Colitis, Ulcerative (D003093)
Colitis (D003092)
DNA, Complementary (D018076)
Chemokines, CXC (D019743)
Chemokine CXCL1 (D054360)
Mucous Membrane (D009092)
Biopsy (D001706)
colon (MA:0000335)
colitis (MP:0002816)
abnormal inflammatory response (MP:0001845)
gene expression (GO:0010467)

Gene List • 6 Genes

Uploaded As Gene Symbol Homology Score Priority LinkOuts Emphasis  

Manage GeneSets

Analyze GeneSets

Manage Accounts

GeneWeaver Links

Policies


Supported by NIH R01 AA18776 jointly funded by NIAAA and NIDA, and JAX Center for Precision Genetics NIH U54 OD 020351