GeneSet Information

Tier III GS75661 • Transcription Factors Deregulated in Colorectal Cancer

DESCRIPTION:

By comparing transcript profiles of normal mucosa and CRC samples in two independent sample sets, covering a total of 20 normal mucosa and 424 adenocarcinoma samples, we identified 51 TFs that showed a significant (P<10−4, Benjamini and Hochberg corrected) fold change (of at least 2) from normal to cancer in both data sets.

LABEL:

Tran.Fac. Col.Can.

SCORE TYPE:

P-Value

DATE ADDED:

2010-06-23

DATE UPDATED:

2020-05-06

SPECIES:

AUTHORS:

Andersen CL, Christensen LL, Thorsen K, Schepeler T, Srensen FB, Verspaget HW, Simon R, Kruhffer M, Aaltonen LA, Laurberg S, rntoft TF

TITLE:

Dysregulation of the transcription factors SOX4, CBFB and SMARCC1 correlates with outcome of colorectal cancer.

JOURNAL:

British journal of cancer Feb 2009, Vol 100, pp. 511-23

ABSTRACT:

The aim of this study was to identify deregulated transcription factors (TFs) in colorectal cancer (CRC) and to evaluate their relation with the recurrence of stage II CRC and overall survival. Microarray-based transcript profiles of 20 normal mucosas and 424 CRC samples were used to identify 51 TFs displaying differential transcript levels between normal mucosa and CRC. For a subset of these we provide in vitro evidence that deregulation of the Wnt signalling pathway can lead to the alterations observed in tissues. Furthermore, in two independent cohorts of microsatellite-stable stage II cancers we found that high SOX4 transcript levels correlated with recurrence (HR 2.7; 95% CI, 1.2-6.0; P=0.01). Analyses of approximately 1000 stage I-III adenocarcinomas, by immunohistochemistry, revealed that patients with tumours displaying high levels of CBFB and SMARCC1 proteins had a significantly better overall survival rate (P=0.0001 and P=0.0275, respectively) than patients with low levels. Multivariate analyses revealed that a high CBFB protein level was an independent predictor of survival. In conclusion, several of the identified TFs seem to be involved in the progression of CRC. PUBMED: 19156145
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Annotation Information

No sequence read archive data associated with this GeneSet.


Humans (D006801)
Adenocarcinoma (D000230)
Cell Line, Tumor (D045744)
Survival Rate (D015996)
Multivariate Analysis (D015999)
Colorectal Neoplasms (D015179)
Patients (D010361)
Recurrence (D012008)
Microsatellite Repeats (D018895)
Adult (D000328)
Immunohistochemistry (D007150)
RNA, Messenger (D012333)
Neoplasms (D009369)
Survival Analysis (D016019)
Middle Aged (D008875)
Proteins (D011506)
Overall (D016424)
Reverse Transcriptase Polymerase Chain Reaction (D020133)
Tissues (D014024)
In Vitro (D007176)
Transcription Factors (D014157)
Lead (D007854)
Core Binding Factor beta Subunit (D050658)
Aged (D000368)
Aged, 80 and over (D000369)
Survival (D013534)
SOXC Transcription Factors (D055751)
Mucous Membrane (D009092)
adenocarcinoma (MP:0009308)
signaling (GO:0023052)

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Supported by NIH R01 AA18776 jointly funded by NIAAA and NIDA, and JAX Center for Precision Genetics NIH U54 OD 020351