GeneSet Information

Tier III GS75643 • Genes regulated by heroin in mouse striatum, 1h

DESCRIPTION:

from Piechota et al., 2010

LABEL:

heroin striatum 1h

SCORE TYPE:

P-Value

THRESHOLD:

<= 0.05

GENES IN THRESHOLD:

8

DATE ADDED:

2010-06-23

DATE UPDATED:

2024-10-22

SPECIES:

AUTHORS:

Piechota M, Korostynski M, Solecki W, Gieryk A, Slezak M, Bilecki W, Ziolkowska B, Kostrzewa E, Cymerman I, Swiech L, Jaworski J, Przewlocki R

TITLE:

The dissection of transcriptional modules regulated by various drugs of abuse in the mouse striatum.

JOURNAL:

Genome biology May 2010, Vol 11, pp. R48

ABSTRACT:

Various drugs of abuse activate intracellular pathways in the brain reward system. These pathways regulate the expression of genes that are essential to the development of addiction. To reveal genes common and distinct for different classes of drugs of abuse, we compared the effects of nicotine, ethanol, cocaine, morphine, heroin and methamphetamine on gene expression profiles in the mouse striatum.We applied whole-genome microarray profiling to evaluate detailed time-courses (1, 2, 4 and 8 hours) of transcriptome alterations following acute drug administration in mice. We identified 42 drug-responsive genes that were segregated into two main transcriptional modules. The first module consisted of activity-dependent transcripts (including Fos and Npas4), which are induced by psychostimulants and opioids. The second group of genes (including Fkbp5 and S3-12), which are controlled, in part, by the release of steroid hormones, was strongly activated by ethanol and opioids. Using pharmacological tools, we were able to inhibit the induction of particular modules of drug-related genomic profiles. We selected a subset of genes for validation by in situ hybridization and quantitative PCR. We also showed that knockdown of the drug-responsive genes Sgk1 and Tsc22d3 resulted in alterations to dendritic spines in mice, possibly reflecting an altered potential for plastic changes.Our study identified modules of drug-induced genes that share functional relationships. These genes may play a critical role in the early stages of addiction. PUBMED: 20459597
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Annotation Information

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Brain (D001921)
Gene Expression Regulation (D005786)
Animals (D000818)
Street Drugs (D013287)
Play and Playthings (D010988)
Reproducibility of Results (D015203)
Polymerase Chain Reaction (D016133)
Mice (D051379)
Gene Regulatory Networks (D053263)
Substance-Related Disorders (D019966)
Gene Expression Profiling (D020869)
Behavior, Animal (D001522)
Dissection (D004210)
Methamphetamine (D008694)
Central Nervous System Stimulants (D000697)
RNA, Messenger (D012333)
Chromosomes, Mammalian (D033481)
Role (D012380)
In Situ Hybridization (D017403)
Dendritic Spines (D049229)
Binding Sites (D001665)
Pharmaceutical Preparations (D004364)
Oligonucleotide Array Sequence Analysis (D020411)
Cocaine (D003042)
Mice, Inbred C57BL (D008810)
Cells, Cultured (D002478)
Transcription, Genetic (D014158)
Transcription Factors (D014157)
Organization and Administration (D009934)
Heroin (D003932)
Neostriatum (D017072)
Reward (D012201)
Hormones (D006728)
Morphine (D009020)
Plastics (D010969)
Gene Knockdown Techniques (D055785)
Ethanol (D000431)
Nicotine (D009538)
Analysis of Variance (D000704)
Analgesics, Opioid (D000701)
Cluster Analysis (D016000)
striatum (MA:0000891)
brain (MA:0000168)
addiction (MP:0002555)
intracellular (GO:0005622)
gene expression (GO:0010467)
Trait (VT:0000001)
response to addictive substance trait (VT:0010488)
response to xenobiotic stimulus trait (VT:0010487)
organism trait (VT:0010454)

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Supported by NIH R01 AA18776 jointly funded by NIAAA and NIDA, and JAX Center for Precision Genetics NIH U54 OD 020351

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