GeneSet Information

Tier III GS75606 • Frontal cortex gene expression in alcoholic vs nonalcoholic humans 2

DESCRIPTION:

from Lewohl et al., 2000; from case group two (male uncomplicated alcoholics)

LABEL:

Alcoholic Frontal Cortex Case 2

SCORE TYPE:

Effect

DATE ADDED:

2010-06-22

DATE UPDATED:

2020-05-06

SPECIES:

AUTHORS:

Lewohl JM, Wang L, Miles MF, Zhang L, Dodd PR, Harris RA

TITLE:

Gene expression in human alcoholism: microarray analysis of frontal cortex.

JOURNAL:

Alcoholism, clinical and experimental research Dec 2000, Vol 24, pp. 1873-82

ABSTRACT:

Changes in brain gene expression are thought to be responsible for the tolerance, dependence, and neurotoxicity produced by chronic alcohol abuse, but there has been no large scale study of gene expression in human alcoholism.RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. We used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays.Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics. Analysis of these changes revealed a selective reprogramming of gene expression in this brain region, particularly for myelin-related genes which were down-regulated in the alcoholic samples. In addition, cell cycle genes and several neuronal genes were changed in expression.These gene expression changes suggest a mechanism for the loss of cerebral white matter in alcoholics as well as alterations that may lead to the neurotoxic actions of ethanol. PUBMED: 11141048
Find other GeneSets from this publication

Annotation Information

No sequence read archive data associated with this GeneSet.


Brain (D001921)
Frontal Lobe (D005625)
RNA (D012313)
Humans (D006801)
Myelin Proteins (D009185)
Genes, cdc (D018816)
Microarray Analysis (D046228)
Middle Aged (D008875)
Down-Regulation (D015536)
European Continental Ancestry Group (D044465)
Oligonucleotide Array Sequence Analysis (D020411)
Cells (D002477)
Alcoholics (D057229)
Lead (D007854)
Methods (D008722)
DNA, Complementary (D018076)
Aged (D000368)
Aged, 80 and over (D000369)
Cell Cycle (D002453)
Alcoholism (D000437)
Ethanol (D000431)
white matter (MA:0001135)
frontal cortex (MA:0000905)
brain (MA:0000168)
cerebral white matter (MA:0000945)
cell (GO:0005623)
cell cycle (GO:0007049)
gene expression (GO:0010467)

Gene List • 133 Genes

Uploaded As Gene Symbol Homology Score Priority LinkOuts Emphasis  

Manage GeneSets

Analyze GeneSets

Manage Accounts

GeneWeaver Links

Policies


Supported by NIH R01 AA18776 jointly funded by NIAAA and NIDA, and JAX Center for Precision Genetics NIH U54 OD 020351