GeneSet Information

Tier III GS75589 • Cocaine Regulation of H4 Acetylation

DESCRIPTION:

from Renthal et al., 2009

LABEL:

h4 acetylation c57

SCORE TYPE:

Effect

DATE ADDED:

2010-06-21

DATE UPDATED:

2019-01-07

SPECIES:

AUTHORS:

Renthal W, Kumar A, Xiao G, Wilkinson M, Covington HE 3rd, Maze I, Sikder D, Robison AJ, LaPlant Q, Dietz DM, Russo SJ, Vialou V, Chakravarty S, Kodadek TJ, Stack A, Kabbaj M, Nestler EJ

TITLE:

Genome-wide analysis of chromatin regulation by cocaine reveals a role for sirtuins.

JOURNAL:

Neuron May 2009, Vol 62, pp. 335-48

ABSTRACT:

Changes in gene expression contribute to the long-lasting regulation of the brain\'s reward circuitry seen in drug addiction; however, the specific genes regulated and the transcriptional mechanisms underlying such regulation remain poorly understood. Here, we used chromatin immunoprecipitation coupled with promoter microarray analysis to characterize genome-wide chromatin changes in the mouse nucleus accumbens, a crucial brain reward region, after repeated cocaine administration. Our findings reveal several interesting principles of gene regulation by cocaine and of the role of DeltaFosB and CREB, two prominent cocaine-induced transcription factors, in this brain region. The findings also provide comprehensive insight into the molecular pathways regulated by cocaine-including a new role for sirtuins (Sirt1 and Sirt2)-which are induced in the nucleus accumbens by cocaine and, in turn, dramatically enhance the behavioral effects of the drug. PUBMED: 19447090
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Annotation Information



Social Control, Formal (D012926)
Gene Expression Regulation (D005786)
Proto-Oncogene Proteins c-fos (D016760)
Animals (D000818)
Reinforcement (Psychology) (D012054)
Promoter Regions, Genetic (D011401)
Substance-Related Disorders (D019966)
Sirtuins (D037761)
Chromatin Immunoprecipitation (D047369)
Microarray Analysis (D046228)
Genome-Wide Association Study (D055106)
Dopamine Uptake Inhibitors (D018765)
Immunoprecipitation (D047468)
Acetylation (D000107)
Nucleus Accumbens (D009714)
Oligonucleotide Array Sequence Analysis (D020411)
Cocaine (D003042)
Mice, Inbred C57BL (D008810)
Transcription Factors (D014157)
Feedback, Physiological (D025461)
Organization and Administration (D009934)
Chromatin (D002843)
Signal Transduction (D015398)
Cyclic AMP Response Element-Binding Protein (D017362)
addiction (MP:0002555)
chromatin (GO:0000785)
gene expression (GO:0010467)

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