DESCRIPTION:

BXD forebrain correlates of EtOH Pref Female Forebrain gene expression genetic correlates of EtOH preference in female BXD mice

LABEL:

EtOH_pref_F_BXD

SCORE TYPE:

Correlation

DATE ADDED:

2007-09-16

DATE UPDATED:

2020-05-06

SPECIES:

AUTHORS:

Rodriguez LA, Plomin R, Blizard DA, Jones BC, McClearn GE

TITLE:

Alcohol acceptance, preference, and sensitivity in mice. I. Quantitative genetic analysis using BXD recombinant inbred strains.

JOURNAL:

Alcoholism, clinical and experimental research Dec 1994, Vol 18, pp. 1416-22

ABSTRACT:

Although the recombinant inbred strain method was designed for molecular genetic analysis of linkage, it also provides powerful quantitative genetic analyses of heritability and genetic correlations. Measures of alcohol acceptance, alcohol preference, and hypnotic dose sensitivity (HDS) were assessed in 21 strains of mice from the BXD RI series. Sex differences were found to be significant at a phenotypic level. However, heritability estimates for acceptance, preference, and HDS are similar in males and females. Heritability estimates for the three measures are approximately 0.20 for acceptance and preference, and 0.10 for HDS. Analyses of genetic correlations reveal that acceptance and preference share some degree of genetic influence, although they mostly operate under different genetically mediated mechanisms. HDS did not show a significant genetic relationship to either acceptance or preference. Strong correlations were obtained when acceptance, preference, and HDS strain means were correlated across male and female recombinant inbreds, suggesting substantial genetic similarity across sexes. PUBMED: 7695038
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