DESCRIPTION:
Mice carrying an A112G (G/G and A/G) substitution are mouse models of the human A118G SNP. In these mice, a point mutation analogous to the human OPRM1 A118G SNP was created at the analogous 112 base position in the mu-opioid receptor gene (Mague et al., 2009). This study modeled sequential injection of oxycodone and cocaine, in two consecutive periods within daily sessions, rather than as a concomitant injection. The current study explored for the first time, how this major functional SNP can affect vulnerability to dual oxycodone and cocaine self-administration; and how chronic self-administration of oxycodone and cocaine impacts the expression of major reward-related genes in the dorsal striatum of A112G mice and their wild type littermates. The custom RT2 Profiler™ PCR Array (AAPA3800-1: CLAM45539, Qiagen) used for the present study measures the expression of 24 genes related to reward, drugs of abuse, and stress responsivity (see Table 1). This array was based on prior studies in this laboratory and others, focusing on genes shown to be responsive to exposure to MOP-r agonists or cocaine, and genes involved in the hypothalamic–pituitary–adrenal (HPA) stress axis (e.g., Piechota et al., 2010; Zhang et al., 2018, 2014, 2012). From Table 1.
LABEL:
A112G mouse mRNA level change in drug SA vs control_pvalue
SCORE TYPE:
P-Value
THRESHOLD:
<= 0.5
GENES IN THRESHOLD:
5
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DATE UPDATED:
SPECIES:
AUTHORS:
TITLE:
JOURNAL:
ABSTRACT:
Genes in threshold: 5
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