DESCRIPTION:
List of Genes located within the associated intervals. ADHD patients were recruited through a Norwegian national medical registry as well as by psychologists and psychiatrists working at out-patient clinics. ADHD diagnosis was defined according to DSM-IV criteria. Controls were randomly recruited through the Norwegian Medical Birth registry. All participants provided either blood or saliva samples for DNA extraction. Participants were genotyped on either Human OmniExpress-12v1-1_B (Illumina, San Diego, CA, USA) or Human OmniExpress-12v1_H (Illumina, San Diego, CA, USA) platforms. Each SNP was tested for association with ADHD in the form of logistic regression assuming an underlying additive model and adjusted for gender as implemented in PLINK. Because participants were genotyped on different arrays, SNPs showing high discrepancy in their frequencies between the two arrays (p<1.00E-05) were excluded from GWA analysis. To evaluate if any known biological pathways were implicated by our GWAS results, intervals around top SNPs (p<1.00E-04) were tested for enrichment in Gene Ontology (GO) nodes using the INRICH software. Using the same association intervals as determined in INRICH enrichment analysis, we assessed possible physical interactions between proteins encoded in those intervals using DAPPLE software. DAPPLE identifies direct and indirect networks from proteins encoded in associated intervals by utilizing experimentally validated, protein-protein interaction databases. As a result, DAPPLE assesses if the connectivity between associated proteins would be greater than expected by chance. This gene list was contained within linkage disequilibrium-independent intervals that were tested for protein-protein interaction in DAPPLE software.
LABEL:
Genes within ADHD-associated positions
SCORE TYPE:
Binary
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| Uploaded As | Gene Symbol | Homology | Score | Priority | LinkOuts | Emphasis |
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