DESCRIPTION:
Based on the disinhibited externalizing spectrum described by Krueger et al. (1), we collected GWAS summary statistics for 13 externalizing phenotypes (Table 1). Only samples with a European/North-American ancestry (23) were included (see Supplement 1). Assessment of genetic resemblance indicated a categorization into two externalizing-related factors, one characterized by disruptive behavior (DB) and another by risk-taking behavior (RTB), that together explained 53% of the total genetic variance. Hierarchical clustering on genetic resemblance (Figure 1B) confirmed this categorization into DBs (aggression, angry outbursts, different measures of irritability, and ADHD) and RTBs (antisocial behavior, general risk tolerance, drinks per week, ever smoker, number of sexual partners, automobile speeding propensity, and lifetime cannabis use). For these phenotypes, we followed the hierarchical clustering results, assigning ADHD to factor 1 (DB) and antisocial behavior to factor 2 (RTB). The author defined alpha level for significant associations in this geneset is alpha = 2.75E-06 (table S13).
LABEL:
DB human gene association_pvalue
SCORE TYPE:
P-Value
THRESHOLD:
<= 0.5
GENES IN THRESHOLD:
12133
DATE ADDED:
DATE UPDATED:
SPECIES:
AUTHORS:
TITLE:
JOURNAL:
ABSTRACT:
Genes in threshold: 12133
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