DESCRIPTION:
RNA-seq was performed on PFC, dorsal striatum (DStr), NAc, basolateral amygdala (BLA), ventral hippocampus (vHIP), and VTA, obtained from the following six groups of male C57BL/6J mice (Figure 1A): saline SA + 24 hr withdrawal (WD) (S24, n=5–8); cocaine SA + 24 hr WD (C24, n=5–8); saline SA + 30 d WD + saline re-exposure (SS, n=5–8); saline SA + 30 d WD + cocaine exposure (SC, n=5–8); cocaine SA + 30 d WD + saline exposure (CS, n=3–7); and cocaine SA + 30 d WD + cocaine re-exposure (CC, n=5–7). To focus on genes that were uniquely altered following context/drug re-exposure after WD, we compared all groups to the same baseline (S24). We focused on three patterns associated with drug use: first-ever exposure to cocaine (SC; Pattern A; Figure 2B), re-exposure to cocaine-paired context (CS, Pattern B, Figure 2C), and re-exposure to cocaine-paired context + cocaine (CC, Pattern C, Figure 2D). Each Pattern includes genes that were both differentially expressed from S24 (p<0.05; fold change>15%) and distinct from all other groups. The pattern C genes were significantly differentially expressed (see above) between the cocaine SA with cocaine re-exposure after 30 days and baseline (i.e. CC vs S4). Differential expression of the pattern C genes are presented for each group (C24 vs S24, SS vs S4, SC vs S4, CS vs S4, and CC vs S4).
LABEL:
Gene expression mouse NAc pattern C CC vs S24_pvalue
SCORE TYPE:
P-Value
THRESHOLD:
<= 0.05
GENES IN THRESHOLD:
372
DATE ADDED:
DATE UPDATED:
SPECIES:
AUTHORS:
TITLE:
JOURNAL:
ABSTRACT:
Genes in threshold: 372
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