DESCRIPTION:
Lists of differentially expressed RNAs. Genes met cutoff criteria padj < 0.2 and |FC| > 1.5. Using next-generation RNA sequencing, authors identified 394 differentially expressed (DE) coding and long noncoding (lnc) RNAs as well as 213 DE proteins in Brodmann Area 9 of opioid use disorder subjects (postmortem human brain). The RNA and protein changes converged on pro-angiogenic gene networks and cytokine signaling pathways. Four genes (LGALS3, SLC2A1, PCLD1, and VAMP1) were dysregulated in both RNA and protein. Dissecting these DE genes and networks, we found cell type-specific effects with enrichment in astrocyte, endothelial, and microglia correlated genes.
LABEL:
Opioid_postmortem human brain_qvalue
SCORE TYPE:
Q-Value
DATE ADDED:
DATE UPDATED:
SPECIES:
AUTHORS:
TITLE:
JOURNAL:
ABSTRACT:
| Uploaded As | Gene Symbol | Homology | Score | Priority | LinkOuts | Emphasis |
|---|
GeneWeaver