DESCRIPTION:
Duchenne Muscular Dystrophy (DMD) is an X-linked neuromuscular disease. It is caused by mutations within the DMD gene, resulting in the absence of Dystrophin (DYS) protein leading to muscle weakness and wasting, owing to the loss of muscle membrane integrity and susceptibility to stress-induced damages. The major cause of death is dilated cardiomyopathy, and existing cellular and animal models do not fully recapitulate the human disease phenotypes. This study generated cardiac organoids from patient-derived induced pluripotent stem cells (DMD-COs) and isogenic-corrected controls (DMD-Iso-COs). Expression values were calculated by the method detailed in 'HBA-DEALS: accurate and simultaneous identification of differential expression and splicing using hierarchical Bayesian analysis' (Genome Biol. 2020, PMID: 32660516), and log base 2 of the fold change are presented with a FDR of <0.05. Down regulated genes were annotated as Ensembl gene ids. SRA Study id SRP356496.
LABEL:
Down regulated genes from DMD-COs compared to DMD-Iso-COs
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Effect
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