DESCRIPTION:
Transcriptome profiling from macular retina and RPE/choroid samples from 27 unrelated eye tissue donors, was performed using RNA-sequencing. Human donor eye collection were obtained from Utah Lions Eye Bank within a 6-hour post-mortem interval and donors aged 60-90 years. Age Related Macular Degeneration (AMD) phenotyping was determined using the Age-Related Eye Disease Study (AREDS) severity grading scale, where AREDS category 0/1 was considered normal, AREDS category 3 intermediate AMD, and AREDS category 4b neovascular AMD. The top ten significantly differentially expressed genes from samples with Intermediate AMD compared with those from Neovascular Normal Macular Retina Pigment epithelium (RPE)/choroid are presented with fold change and P < 0.05. This gene set was annotated from Table 2 of BioRxiv pre-print paper ‘Patterns of gene expression and allele-specific expression vary among macular tissues and clinical stages of Age-related Macular Degeneration’ by Zhang et.al (2022) doi: https://doi.org/10.1101/2022.12.19.521092
LABEL:
Top 10 differentially expressed genes from Intermediate AMD compared to Neovascular RPE/choriod
SCORE TYPE:
Effect
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