DESCRIPTION:
Transcriptome profiling from macular retina and RPE/choroid samples from 27 unrelated eye tissue donors, was performed using RNA-sequencing. Human donor eye collection were obtained from Utah Lions Eye Bank within a 6-hour post-mortem interval and donors aged 60-90 years. Age Related Macular Degeneration (AMD) phenotyping was determined using the Age-Related Eye Disease Study (AREDS) severity grading scale, where AREDS category 0/1 was considered normal, AREDS category 3 intermediate AMD, and AREDS category 4b neovascular AMD. The top ten significantly differentially expressed genes from samples with Neovascular AMD compared with those from Normal Macular Retina Pigment epithelium (RPE)/choroid are presented with fold change and P < 0.05. This gene set was annotated from Table 2 of BioRxiv pre-print paper ‘Patterns of gene expression and allele-specific expression vary among macular tissues and clinical stages of Age-related Macular Degeneration’ by Zhang et.al (2022) doi: https://doi.org/10.1101/2022.12.19.521092
LABEL:
Top 10 differentially expressed genes from Neovascular AMD compared to Normal RPE/choriod
SCORE TYPE:
Effect
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