DESCRIPTION:

Genes up-regulated in various immune cells cells present in blood from MIS-C patients compared to healthy child donors. Genes which exhibited increased expression in some cell types and decreased expression in other cell types were included in this set. Genes from each tab (NaïveCD8, MemoryCD8, NKcell, NaïveCD4, MemoryCD4, Treg, NaïveB, MemoryB, Monocytes, Neutrophils, cDCs, pDCs) of s3-table-S6-mmc3.xlxs were assigned a category based on their cell type (indcated by the tab name) and whether they were up or down regulated (indicated by a positive or negative value in the "avg_logFC" column, e.g. either "NaïveCD8 up" or "NaïveCD8 down" for markers present in the "NaïveCD8" tab. Gene were entered as HGNC IDs. 13 Markers could not be mapped at HGNC (43893, 44075, AC004865.2, AC007952.4, AC020636.1, AC020656.1, AC119396.1, AC243960.1, AC245014.3, AL360270.1, AL445524.1).

LABEL:

Variable_differential_expression_in_blood_immune_cells_MIS-C

SCORE TYPE:

Binary

DATE ADDED:

2021-09-13

DATE UPDATED:

2021-09-13

SPECIES:

AUTHORS:

Anjali Ramaswamy, Nina N Brodsky, Tomokazu S Sumida, Michela Comi, Hiromitsu Asashima, Kenneth B Hoehn, Ningshan Li, Yunqing Liu, Aagam Shah, Neal G Ravindra, Jason Bishai, Alamzeb Khan, William Lau, Brian Sellers, Neha Bansal, Pamela Guerrerio, Avraham Unterman, Victoria Habet, Andrew J Rice, Jason Catanzaro, Harsha Chandnani, Merrick Lopez, Naftali Kaminski, Charles S Dela Cruz, John S Tsang, Zuoheng Wang, Xiting Yan, Steven H Kleinstein, David van Dijk, Richard W Pierce, David A Hafler, Carrie L Lucas

TITLE:

Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children.

JOURNAL:

Immunity 05 2021, Vol 54, pp. 1083-1095.e7

ABSTRACT:

Multisystem inflammatory syndrome in children (MIS-C) is a life-threatening post-infectious complication occurring unpredictably weeks after mild or asymptomatic SARS-CoV-2 infection. We profiled MIS-C, adult COVID-19, and healthy pediatric and adult individuals using single-cell RNA sequencing, flow cytometry, antigen receptor repertoire analysis, and unbiased serum proteomics, which collectively identified a signature in MIS-C patients that correlated with disease severity. Despite having no evidence of active infection, MIS-C patients had elevated S100A-family alarmins and decreased antigen presentation signatures, indicative of myeloid dysfunction. MIS-C patients showed elevated expression of cytotoxicity genes in NK and CD8 PUBMED: 33891889
Find other GeneSets from this publication