DESCRIPTION:

Genes up-regulated in various immune cells cells present in blood from MIS-C patients compared to healthy child donors. Genes from each tab (NaïveCD8, MemoryCD8, NKcell, NaïveCD4, MemoryCD4, Treg, NaïveB, MemoryB, Monocytes, Neutrophils, cDCs, pDCs) of s3-table-S6-mmc3.xlxs were assigned a category based on their cell type (indicated by the tab name) and whether they were up or down regulated (indicated by a positive or negative value in the "avg_logFC" column, e.g. either "NaïveCD8 up" or "NaïveCD8 down" for markers present in the "NaïveCD8" tab. Note that the cut-off for differentially expressed genes was greater than absolute value of 0.5, rather than greater than absolute value of 1. Genes which exhibited decreased gene expression in all cell types in which they exhibited a change in expression level were included in this set. 34 genes which had increased expression in some cell types and decreased expression in other cell types were excluded (HGNC:1130, HGNC:6727, HGNC:10488, HGNC:4938, HGNC:4940, HGNC:4948, HGNC:4953, HGNC:10630, HGNC:3068, HGNC:3443, HGNC:6204, HGNC:1711, HGNC:347, HGNC:533, HGNC:537, HGNC:14130, HGNC:7082, HGNC:2771, HGNC:2479, HGNC:30239, HGNC:3288, HGNC:3796, HGNC:4638, HGNC:6153, HGNC:6175, HGNC:6408, HGNC:6860, HGNC:7406, HGNC:13880, HGNC:672, HGNC:10368, HGNC:11554, HGNC:2464, HGNC:17521). The text strings "3-Mar" and "6-Sep" present in one or more Marker columns were converted to "MAR3" and "SEPT6" respectively. Genes were entered as HGNC IDs. 13 Markers could not be mapped at HGNC (43893, 44075, AC004865.2, AC007952.4, AC020636.1, AC020656.1, AC119396.1, AC243960.1, AC245014.3, AL360270.1, AL445524.1). The ID HGNC:32393 was not found in GeneWeaver.

LABEL:

Up_in_blood_immune_cells_MIS-C

SCORE TYPE:

Binary

DATE ADDED:

2021-09-11

DATE UPDATED:

2021-09-13

SPECIES:

AUTHORS:

Anjali Ramaswamy, Nina N Brodsky, Tomokazu S Sumida, Michela Comi, Hiromitsu Asashima, Kenneth B Hoehn, Ningshan Li, Yunqing Liu, Aagam Shah, Neal G Ravindra, Jason Bishai, Alamzeb Khan, William Lau, Brian Sellers, Neha Bansal, Pamela Guerrerio, Avraham Unterman, Victoria Habet, Andrew J Rice, Jason Catanzaro, Harsha Chandnani, Merrick Lopez, Naftali Kaminski, Charles S Dela Cruz, John S Tsang, Zuoheng Wang, Xiting Yan, Steven H Kleinstein, David van Dijk, Richard W Pierce, David A Hafler, Carrie L Lucas

TITLE:

Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children.

JOURNAL:

Immunity 05 2021, Vol 54, pp. 1083-1095.e7

ABSTRACT:

Multisystem inflammatory syndrome in children (MIS-C) is a life-threatening post-infectious complication occurring unpredictably weeks after mild or asymptomatic SARS-CoV-2 infection. We profiled MIS-C, adult COVID-19, and healthy pediatric and adult individuals using single-cell RNA sequencing, flow cytometry, antigen receptor repertoire analysis, and unbiased serum proteomics, which collectively identified a signature in MIS-C patients that correlated with disease severity. Despite having no evidence of active infection, MIS-C patients had elevated S100A-family alarmins and decreased antigen presentation signatures, indicative of myeloid dysfunction. MIS-C patients showed elevated expression of cytotoxicity genes in NK and CD8 PUBMED: 33891889
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