DESCRIPTION:

This gene set describes genes that are down-regulated in blood of children with COVID-19, the disease caused by SARS-CoV2, versus healthy controls using RNAseq analysis. These children did not have MIS-C. The genes were filtered for a p-value < 0.05 and a log fold-change of greater than 1.0 given in supplemental table 7. Genes were entered into GeneWeaver using the reported EnsEMBL identifiers. Values are log-fold change.

LABEL:

Down in pediatric COVID-19

SCORE TYPE:

Effect

THRESHOLD:

-5.086232792 <=> -1.002238969

GENES IN THRESHOLD:

745

DATE ADDED:

2021-09-03

DATE UPDATED:

2024-10-22

SPECIES:

AUTHORS:

Noam D Beckmann, Phillip H Comella, Esther Cheng, Lauren Lepow, Aviva G Beckmann, Scott R Tyler, Konstantinos Mouskas, Nicole W Simons, Gabriel E Hoffman, Nancy J Francoeur, Diane Marie Del Valle, Gurpawan Kang, Anh Do, Emily Moya, Lillian Wilkins, Jessica Le Berichel, Christie Chang, Robert Marvin, Sharlene Calorossi, Alona Lansky, Laura Walker, Nancy Yi, Alex Yu, Jonathan Chung, Matthew Hartnett, Melody Eaton, Sandra Hatem, Hajra Jamal, Alara Akyatan, Alexandra Tabachnikova, Lora E Liharska, Liam Cotter, Brian Fennessy, Akhil Vaid, Guillermo Barturen, Hardik Shah, Ying-Chih Wang, Shwetha Hara Sridhar, Juan Soto, Swaroop Bose, Kent Madrid, Ethan Ellis, Elyze Merzier, Konstantinos Vlachos, Nataly Fishman, Manying Tin, Melissa Smith, Hui Xie, Manishkumar Patel, Kai Nie, Kimberly Argueta, Jocelyn Harris, Neha Karekar, Craig Batchelor, Jose Lacunza, Mahlet Yishak, Kevin Tuballes, Ieisha Scott, Arvind Kumar, Suraj Jaladanki, Charuta Agashe, Ryan Thompson, Evan Clark, Bojan Losic, Lauren Peters, , Panagiotis Roussos, Jun Zhu, Wenhui Wang, Andrew Kasarskis, Benjamin S Glicksberg, Girish Nadkarni, Dusan Bogunovic, Cordelia Elaiho, Sandeep Gangadharan, George Ofori-Amanfo, Kasey Alesso-Carra, Kenan Onel, Karen M Wilson, Carmen Argmann, Supinda Bunyavanich, Marta E Alarcón-Riquelme, Thomas U Marron, Adeeb Rahman, Seunghee Kim-Schulze, Sacha Gnjatic, Bruce D Gelb, Miriam Merad, Robert Sebra, Eric E Schadt, Alexander W Charney

TITLE:

Downregulation of exhausted cytotoxic T cells in gene expression networks of multisystem inflammatory syndrome in children.

JOURNAL:

Nature communications 08 2021, Vol 12, pp. 4854

ABSTRACT:

Multisystem inflammatory syndrome in children (MIS-C) presents with fever, inflammation and pathology of multiple organs in individuals under 21 years of age in the weeks following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Although an autoimmune pathogenesis has been proposed, the genes, pathways and cell types causal to this new disease remain unknown. Here we perform RNA sequencing of blood from patients with MIS-C and controls to find disease-associated genes clustered in a co-expression module annotated to CD56 PUBMED: 34381049
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