DESCRIPTION:

Genes that are significantly associated with methamphetamine use disorder in humans based on a meta-analysis of genome-wide association studies in the literature. Data taken from Table 3. Values presented are ""1"" for presence."

LABEL:

human meth markers

SCORE TYPE:

Binary

DATE ADDED:

2021-07-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Alexandre A Guerin, Eric J Nestler, Michael Berk, Andrew J Lawrence, Susan L Rossell, Jee Hyun Kim

TITLE:

Genetics of methamphetamine use disorder: A systematic review and meta-analyses of gene association studies.

JOURNAL:

Neuroscience and biobehavioral reviews 01 2021, Vol 120, pp. 48-74

ABSTRACT:

Genetic susceptibility to methamphetamine use disorder is poorly understood. No twin or adequately powered genome-wide association studies (GWASs) have been conducted. However, there are a large number of hypothesis-driven candidate gene association studies, which were systematically reviewed herein. Seventy-six studies were identified, investigating markers of 75 different genes. Allele frequencies, odds ratios, 95 % confidence intervals and power were calculated. Risk of bias was also assessed as a quality measure. Meta-analyses were conducted for gene markers if three or more studies were available. Eleven markers from adequately powered studies were significantly associated with methamphetamine use disorder, with Fatty Acid Amide Hydrolase (FAAH) and Brain Derived Neurotrophic Factor (BDNF) representing promising targets. Limitations of these studies include unclear rationale for candidate gene selection, low power and high risk of bias. Future research should include replications to enable more meta-analyses, well-powered GWASs or whole exome or genome sequencing, as well as twin and family studies to further complement the findings of this review to uncover genetic contributions toward methamphetamine use disorder. PUBMED: 33217458
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