DESCRIPTION:

This set includes genes that are downregulated in granulocytes from patients with severe versus mild disease at a late stage. Early stage was considered to be later than 10 days after symptoms. Genes from table S4 were entered using ENSEMBL identifiers. Values given are log2 fold change in expression levels.

LABEL:

down in late COVID-19 granulocytes, severe vs mild

SCORE TYPE:

Effect

THRESHOLD:

-3.579697374 <=> -1.000317387

GENES IN THRESHOLD:

1788

DATE ADDED:

2021-06-25

DATE UPDATED:

2024-10-22

SPECIES:

AUTHORS:

Anna C Aschenbrenner, Maria Mouktaroudi, Benjamin Krämer, Marie Oestreich, Nikolaos Antonakos, Melanie Nuesch-Germano, Konstantina Gkizeli, Lorenzo Bonaguro, Nico Reusch, Kevin Baßler, Maria Saridaki, Rainer Knoll, Tal Pecht, Theodore S Kapellos, Sarandia Doulou, Charlotte Kröger, Miriam Herbert, Lisa Holsten, Arik Horne, Ioanna D Gemünd, Nikoletta Rovina, Shobhit Agrawal, Kilian Dahm, Martina van Uelft, Anna Drews, Lena Lenkeit, Niklas Bruse, Jelle Gerretsen, Jannik Gierlich, Matthias Becker, Kristian Händler, Michael Kraut, Heidi Theis, Simachew Mengiste, Elena De Domenico, Jonas Schulte-Schrepping, Lea Seep, Jan Raabe, Christoph Hoffmeister, Michael ToVinh, Verena Keitel, Gereon Rieke, Valentina Talevi, Dirk Skowasch, N Ahmad Aziz, Peter Pickkers, Frank L van de Veerdonk, Mihai G Netea, Joachim L Schultze, Matthijs Kox, Monique M B Breteler, Jacob Nattermann, Antonia Koutsoukou, Evangelos J Giamarellos-Bourboulis, Thomas Ulas,

TITLE:

Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients.

JOURNAL:

Genome medicine 01 2021, Vol 13, pp. 7

ABSTRACT:

The SARS-CoV-2 pandemic is currently leading to increasing numbers of COVID-19 patients all over the world. Clinical presentations range from asymptomatic, mild respiratory tract infection, to severe cases with acute respiratory distress syndrome, respiratory failure, and death. Reports on a dysregulated immune system in the severe cases call for a better characterization and understanding of the changes in the immune system. PUBMED: 33441124
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